EFFECT OF CAPTOPRIL ON AQUEOUS HUMOR LEVEL OF ANGIOTENSIN II AND VASCULAR ENDOTHELIAL GROWTH FACTOR IN PATIENTS WITH DIABETIC MACULAR EDEMA

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PEYMAN M.; AMINI HARANDI A.; SHAHSHAHAN M.; BAKHTIARI A.; PEYMAN A.; GHANBARI H.

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Journal: JOURNAL OF MEDICAL RESEARCH (JMR) Year:2005 | Volume:3 | Issue:4 Page(s): 1-9

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Title

EFFECT OF CAPTOPRIL ON AQUEOUS HUMOR LEVEL OF ANGIOTENSIN II AND VASCULAR ENDOTHELIAL GROWTH FACTOR IN PATIENTS WITH DIABETIC MACULAR EDEMA

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Keywords

CAPTOPRILQ4

ANGIOTENSIN IIQ4

VASCULAR ENDOTHELIAL GROWTH FACTORQ4

AQUEOUS HUMORQ4

Abstract

Background: Diabetic macular edema (DME) is the most common cause of decreased visual acuity among diabetic subjects but its pathogenesis is still poorly understood. This study was undertaken to determine if the levels of ANGIOTENSIN II (AII) and other related cytokines in the AQUEOUS HUMOR have any relationship to DME. The effect of CAPTOPRIL administration was also studied in this regard. Patients and Methods: AQUEOUS HUMOR samples were obtained during cataract surgery from 58 eyes of which 37 were diabetic patients. From these subjects, 16 had taken CAPTOPRIL and 21 cases had not taken any angiotensin converting enzyme inhibitors (ACEIs). The level of VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) in the aqueous fluid was measured by enzyme-linked immunosorbent assay. Angiotensin level was assessed by radioimmunoassay. Severity of macular edema was evaluated by clinical examination after surgery. Results: The aqueous levels of ANGIOTENSIN II and VEGF were significantly higher in patients with DME compared to non-diabetic cases (p<0.001 and p=0.0005, respectively). Aqueous concentrations of both ANGIOTENSIN II and VEGF were significantly lower in patients with diabetic macular edema treated with CAPTOPRIL than in patients with diabetic macular edema not treated with ACEIs (p<0.0003 and p<0.0001, respectively). Conclusion: The findings of this study suggest that the aqueous level of ANGIOTENSIN II has a significant correlation with the severity of macular edema and this may play a role in the pathogenesis of macular edema in correlation with VEGF. It seems that modulation of the renin-angiotensin system may become a very important target for drug treatment in patients with DME.

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APA: Copy

PEYMAN, M., AMINI HARANDI, A., SHAHSHAHAN, M., BAKHTIARI, A., PEYMAN, A., & GHANBARI, H.. (2005). EFFECT OF CAPTOPRIL ON AQUEOUS HUMOR LEVEL OF ANGIOTENSIN II AND VASCULAR ENDOTHELIAL GROWTH FACTOR IN PATIENTS WITH DIABETIC MACULAR EDEMA. JOURNAL OF MEDICAL RESEARCH (JMR), 3(4), 1-9. SID. https://sid.ir/paper/105829/en

Vancouver: Copy

PEYMAN M., AMINI HARANDI A., SHAHSHAHAN M., BAKHTIARI A., PEYMAN A., GHANBARI H.. EFFECT OF CAPTOPRIL ON AQUEOUS HUMOR LEVEL OF ANGIOTENSIN II AND VASCULAR ENDOTHELIAL GROWTH FACTOR IN PATIENTS WITH DIABETIC MACULAR EDEMA. JOURNAL OF MEDICAL RESEARCH (JMR)[Internet]. 2005;3(4):1-9. Available from: https://sid.ir/paper/105829/en

IEEE: Copy

M. PEYMAN, A. AMINI HARANDI, M. SHAHSHAHAN, A. BAKHTIARI, A. PEYMAN, and H. GHANBARI, “EFFECT OF CAPTOPRIL ON AQUEOUS HUMOR LEVEL OF ANGIOTENSIN II AND VASCULAR ENDOTHELIAL GROWTH FACTOR IN PATIENTS WITH DIABETIC MACULAR EDEMA,” JOURNAL OF MEDICAL RESEARCH (JMR), vol. 3, no. 4, pp. 1–9, 2005, [Online]. Available: https://sid.ir/paper/105829/en

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