Fluoxetine-induced Hypotension: A Case Report (Case Report)

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HOSSEINI SEYED HAMZEH; ZAMANI NEDA; AHMADI AMIR HOSSEIN

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Journal Paper

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Journal: Pharmaceutical and Biomedical Research Year:2023 | Volume:9 | Issue:1 Page(s): 73-76

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Title

Fluoxetine-induced Hypotension: A Case Report (Case Report)

Author(s)

HOSSEINI SEYED HAMZEH | ZAMANI NEDA | AHMADI AMIR HOSSEIN | Issue Writer Certificate

Keywords

Fluoxetine

hypotension

blood pressure

case report

Abstract

Fluoxetine is a Selective Serotonin Reuptake Inhibitor (SSRI) that exerts its anti-depressive effect by blocking the presynaptic reuptake of the neurotransmitter serotonin, 5-hydroxytryptamine (5-HT). Although Fluoxetine is usually considered safe for most patients, in the present case report, we describe a young patient with Mixed Anxiety and Depression Disorder (MADD) treated with Fluoxetine 10 mg/day, who developed hypotension when the dosage was titrated up to 20 mg/day. After discontinuing the use of Fluoxetine, the symptoms of hypotension improved. A temporal association and dose-dependent relationship between the hypotension and the use of Fluoxetine was observed. To the best of our knowledge, this is the first case report that precisely associates regular doses of Fluoxetine with the presence of hypotension. Because boosting central serotonergic function lowers blood pressure, it is suggested that a significant effect of Fluoxetine on the vasomotor center may be responsible for the reduction of blood pressure. Thus, physicians should be aware of the possible risk of hypotension induced by Fluoxetine and recommend patients discontinue the drug immediately if complications have occurred.

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APA: Copy

HOSSEINI, SEYED HAMZEH, ZAMANI, NEDA, & AHMADI, AMIR HOSSEIN. (2023). Fluoxetine-induced Hypotension: A Case Report (Case Report). PHARMACEUTICAL AND BIOMEDICAL RESEARCH, 9(1), 73-76. SID. https://sid.ir/paper/1068520/en

Vancouver: Copy

HOSSEINI SEYED HAMZEH, ZAMANI NEDA, AHMADI AMIR HOSSEIN. Fluoxetine-induced Hypotension: A Case Report (Case Report). PHARMACEUTICAL AND BIOMEDICAL RESEARCH[Internet]. 2023;9(1):73-76. Available from: https://sid.ir/paper/1068520/en

IEEE: Copy

SEYED HAMZEH HOSSEINI, NEDA ZAMANI, and AMIR HOSSEIN AHMADI, “Fluoxetine-induced Hypotension: A Case Report (Case Report),” PHARMACEUTICAL AND BIOMEDICAL RESEARCH, vol. 9, no. 1, pp. 73–76, 2023, [Online]. Available: https://sid.ir/paper/1068520/en

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