RESPONSE TO SPLENECTOMY IN CHRONIC ITP:A TWENTY YEARS SURVEY IN HAZRAT ALL ASGHAR HOSPITAL

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ARJMANDI RAFSANJANI KHADIJEH; VOSOUGH PARVANEH; KARGAR MOHAMMAD

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Journal: Razi Journal of Medical Sciences Year:2001 | Volume:8 | Issue:25 Page(s): 250-255

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Title

RESPONSE TO SPLENECTOMY IN CHRONIC ITP:A TWENTY YEARS SURVEY IN HAZRAT ALL ASGHAR HOSPITAL

Author(s)

ARJMANDI RAFSANJANI KHADIJEH | VOSOUGH PARVANEH | KARGAR MOHAMMAD | Issue Writer Certificate

Keywords

SPLENECTOMYQ3

CHRONIC ITPQ3

Abstract

ITP is an autoimmune disorder, due to increased platelet destruction. This condition may be acute, chronic or recurrent. In the acute form, the platelet count returns to normal within 6 months after diagnosis. In the chronic form, the platelet count remains low beyond 6 months.In approximately 90% of children ITP is an acute and self-limited disease. SPLENECTOMY is indicated for severe acute ITP with life threatening bleeding, which is nonresponsive to medical treatment.SPLENECTOMY is also indicated in chronic form with bleeding symptoms or persistent platelet count below 30,000/mm3, which is nonresponsive to medical treatment for several years. The platelet count usually rises immediately after SPLENECTOMY, reaching a maximum 1 to 2 weeks postSPLENECTOMY. If the peak of platelet count achived after SPLENECTOMY is above 500,000/mm3, permanent remission is likely. In our study we evaluated 21 patients with CHRONIC ITP that were splenectomized. In 18 patients, the duration of post operation time was over 1 year and in 3 patients it was less than 2 months, so these 3 were not included in our final analysis.We divided the patients in two groups: 1-Group(P): patients responded to SPLENECTOMY (10 patients), rising of platelet count after SPLENECTOMY in 6 patients was greater than 500,000/ mm3 and persistent at least for 1 year, without any medical therapy> 150,000/ mm3.2- Group (N): Patients who did not respond 10 spleneclomy (8 patients). We tried to find correlation between variables, and respond to SPLENECTOMY but because of limited number of patients, we achieved only a significant correlation between postSPLENECTOMY response and patients' age. Patients who had diagnosis of ITP in younger age, had better response to SPLENECTOMY later.A correlation between response to IVIg therapy before SPLENECTOMY and postSPLENECTOMY was also observed. Because half of the patients of P group had platelet count greater than 500,000mm3 with IvIg therapy, so it is concluded that patients who respond well to IVIg therapy in the primary treatment may show a better respond to SPLENECTOMY.

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APA: Copy

ARJMANDI RAFSANJANI, KHADIJEH, VOSOUGH, PARVANEH, & KARGAR, MOHAMMAD. (2001). RESPONSE TO SPLENECTOMY IN CHRONIC ITP:A TWENTY YEARS SURVEY IN HAZRAT ALL ASGHAR HOSPITAL. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 8(25), 250-255. SID. https://sid.ir/paper/10713/en

Vancouver: Copy

ARJMANDI RAFSANJANI KHADIJEH, VOSOUGH PARVANEH, KARGAR MOHAMMAD. RESPONSE TO SPLENECTOMY IN CHRONIC ITP:A TWENTY YEARS SURVEY IN HAZRAT ALL ASGHAR HOSPITAL. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2001;8(25):250-255. Available from: https://sid.ir/paper/10713/en

IEEE: Copy

KHADIJEH ARJMANDI RAFSANJANI, PARVANEH VOSOUGH, and MOHAMMAD KARGAR, “RESPONSE TO SPLENECTOMY IN CHRONIC ITP:A TWENTY YEARS SURVEY IN HAZRAT ALL ASGHAR HOSPITAL,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 8, no. 25, pp. 250–255, 2001, [Online]. Available: https://sid.ir/paper/10713/en

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