GLUTATHIONE REDUCTION IN LIVER TISSUE AFTER RENAL ISCHEMIA REPERFUSION

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KHASTAR HOSSEIN; KADKHODAEE MEHRI; SEIFI BEHJAT; KALALIAN MOGHADDAM HAMID; YARMOHAMMADI MARYAM; AHMADIAN CHASHMI NOOSHIN; KHAKSARI MEHDI

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Journal: KNOWLEDGE AND HEALTH Year:2014 | Volume:9 | Issue:3 Page(s): 77-81

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Title

GLUTATHIONE REDUCTION IN LIVER TISSUE AFTER RENAL ISCHEMIA REPERFUSION

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Keywords

RENAL ISCHEMIAQ3

REMOTE ORGANSQ3

LIVER DAMAGEQ3

LEUKOCYTEQ3

OXIDATIVE STRESSQ2

Abstract

Introduction: RENAL ISCHEMIA reperfusion (IR) is a common cause of acute renal failure. Renal IR induces remote organ dysfunction such as lung, heart and liver. The aim of this study was to assess the role of LEUKOCYTEs on the hepatic tissue glutathione as a liver antioxidant index after renal IR injury.Methods: Inbred mice were subjected to either sham operation (sham donor) or bilateral renal IR injury that undergoes 50 min ischemia followed by 3h reperfusion (IR donor). Mice were then anesthetized for collection of blood and liver samples. LEUKOCYTEs isolated from blood and then were transferred to two recipient groups: recipient mice that received LEUKOCYTEs from sham-operated control mice and intact recipient mice that received LEUKOCYTEs from IR mice. After 24h, recipient mice were anesthetized and blood and liver samples were collected.Results: Hepatic glutathione (GSH) decreased significantly in intact recipient mice that received LEUKOCYTEs from IR mice in comparison to intact recipient mice received LEUKOCYTEs from sham-operated control mice. Conclusion: These results suggest that LEUKOCYTEs are one of the possible factors that contribute to LIVER DAMAGE after renal IR injury and this damage is partly due to the induction of OXIDATIVE STRESS.

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APA: Copy

KHASTAR, HOSSEIN, KADKHODAEE, MEHRI, SEIFI, BEHJAT, KALALIAN MOGHADDAM, HAMID, YARMOHAMMADI, MARYAM, AHMADIAN CHASHMI, NOOSHIN, & KHAKSARI, MEHDI. (2014). GLUTATHIONE REDUCTION IN LIVER TISSUE AFTER RENAL ISCHEMIA REPERFUSION. KNOWLEDGE AND HEALTH, 9(3), 77-81. SID. https://sid.ir/paper/107824/en

Vancouver: Copy

KHASTAR HOSSEIN, KADKHODAEE MEHRI, SEIFI BEHJAT, KALALIAN MOGHADDAM HAMID, YARMOHAMMADI MARYAM, AHMADIAN CHASHMI NOOSHIN, KHAKSARI MEHDI. GLUTATHIONE REDUCTION IN LIVER TISSUE AFTER RENAL ISCHEMIA REPERFUSION. KNOWLEDGE AND HEALTH[Internet]. 2014;9(3):77-81. Available from: https://sid.ir/paper/107824/en

IEEE: Copy

HOSSEIN KHASTAR, MEHRI KADKHODAEE, BEHJAT SEIFI, HAMID KALALIAN MOGHADDAM, MARYAM YARMOHAMMADI, NOOSHIN AHMADIAN CHASHMI, and MEHDI KHAKSARI, “GLUTATHIONE REDUCTION IN LIVER TISSUE AFTER RENAL ISCHEMIA REPERFUSION,” KNOWLEDGE AND HEALTH, vol. 9, no. 3, pp. 77–81, 2014, [Online]. Available: https://sid.ir/paper/107824/en

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