EFFECT OF CHRONIC ADMINISTRATION OF MELATONIN ON TESTICULAR DAMAGE IN STREPTOZOTOCIN- INDUCED DIABETIC MALE RAT

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MOLZEMI SEHAR; SHIRAVI ABDOLHOSAIN; KALALIAN MOGHADDAM HAMID; BABAKHANI ABOLFAZL; GHANBARI FATEMEH

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Journal: KNOWLEDGE AND HEALTH Year:2012 | Volume:7 | Issue:3 Page(s): 136-140

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Title

EFFECT OF CHRONIC ADMINISTRATION OF MELATONIN ON TESTICULAR DAMAGE IN STREPTOZOTOCIN- INDUCED DIABETIC MALE RAT

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Keywords

DIABETESQ3

MELATONINQ2

SPERMATOGENESISQ3

SERTOLI CELLQ3

TESTES INJURYQ3

Abstract

Introduction: DIABETES malady because of making oxidative stress has an important role in causing the metabolism damages. The aim of this study was to assess the effect of MELATONIN with regard to its anti oxidant attribute for treatment of testicular damage of DIABETES.Methods: In this research, 24 male vistar rats with average weight of 200-220g were choosen and divided into 3 groups of control, diabetic and treatment. DIABETES group was induced by Sterptozotosin (STZ) injection(55mg/kg), and treatment group, (diabetic +melatonin), after two months of becoming diabetic received MELATONIN pill with 10mg/kg dose of it in gavage way during 5 weeks. At the start of the fifth week, the blood samples were taken from the rats and biochemical and blood hormones invoices and also testicle sections were histologically evaluated.Results: DIABETES through producing oxidative stresses and producing of free radicals decreases spermatogoni and sertoly cell and also decreases SPERMATOGENESIS and sperm functions. Diabetic also decreases quantity of insulin and testosterone hormones. MELATONIN administration increases amount of plasma insulin and testosterone hormone that significantly decreases the produced morphologic changes.Conclusion: MELATONIN can prevent and cure oxidative stresses and also it can be a cure for testicular damages resulting from DIABETES.

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APA: Copy

MOLZEMI, SEHAR, SHIRAVI, ABDOLHOSAIN, KALALIAN MOGHADDAM, HAMID, BABAKHANI, ABOLFAZL, & GHANBARI, FATEMEH. (2012). EFFECT OF CHRONIC ADMINISTRATION OF MELATONIN ON TESTICULAR DAMAGE IN STREPTOZOTOCIN- INDUCED DIABETIC MALE RAT. KNOWLEDGE AND HEALTH, 7(3), 136-140. SID. https://sid.ir/paper/107971/en

Vancouver: Copy

MOLZEMI SEHAR, SHIRAVI ABDOLHOSAIN, KALALIAN MOGHADDAM HAMID, BABAKHANI ABOLFAZL, GHANBARI FATEMEH. EFFECT OF CHRONIC ADMINISTRATION OF MELATONIN ON TESTICULAR DAMAGE IN STREPTOZOTOCIN- INDUCED DIABETIC MALE RAT. KNOWLEDGE AND HEALTH[Internet]. 2012;7(3):136-140. Available from: https://sid.ir/paper/107971/en

IEEE: Copy

SEHAR MOLZEMI, ABDOLHOSAIN SHIRAVI, HAMID KALALIAN MOGHADDAM, ABOLFAZL BABAKHANI, and FATEMEH GHANBARI, “EFFECT OF CHRONIC ADMINISTRATION OF MELATONIN ON TESTICULAR DAMAGE IN STREPTOZOTOCIN- INDUCED DIABETIC MALE RAT,” KNOWLEDGE AND HEALTH, vol. 7, no. 3, pp. 136–140, 2012, [Online]. Available: https://sid.ir/paper/107971/en

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