INVESTIGATION OF SERUM C-REACTIVE PROTEIN AND MANNOSE-BINDING LECTIN LEVELS IN PATIENTS WITH DERMATOPHYTOSIS

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NAMI SANAM; FALAHATI MEHRABAN; ZEINI FARIDEH; AKHLAGHI LAME; SADRI MOHAMMAD; TABATABAIE FATEMEH; GHASEMI ZEINAB; NOZARI SHIMA

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Journal: Razi Journal of Medical Sciences Year:2011 | Volume:18 | Issue:89 Page(s): 46-53

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Title

INVESTIGATION OF SERUM C-REACTIVE PROTEIN AND MANNOSE-BINDING LECTIN LEVELS IN PATIENTS WITH DERMATOPHYTOSIS

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DERMATOPHYTOSISQ3

CRPQ2

MBLQ2

Abstract

Background: DERMATOPHYTOSIS is common cutaneous fungal disease with worldwide distribution. Interleukin8 (IL-8) realized from keratinocytes in the presence of dermatophytic antigens causes induction of acute responses in dermatophyte infection and subsequently production of acute phase proteins occurs in hepatocytes. C-reactive protein (CRP) and Mannose-binding lectin (MBL) are acute phase proteins. Since few researches in the case of acute phase proteins in dermatophytic infections has been accomplished, this study has been designed for determining serum CRP and MBL levels in patients affected to DERMATOPHYTOSIS.Methods: This was a cross sectional study and samples were carried out on 96 healthy individuals and 105 patients affected to DERMATOPHYTOSIS with non probable and in access procedure. For isolation and identification of dermatophyte direct microscopic examination, culturing and complementary examinations were done and for determination of serum CRP and MBL levels in healthy individuals and in patients ELISA test were used. For investigation of relevance between variables, Chi-square, Fisher exact, Mann-Whitney and Roc curve analysis were used and p< 0.05 was considered as meaningful level.Results: The median serum CRP level in healthy individuals and in patients group was 3.31±3.32 mg/ml and 16.60±35.96 mg/ml (p<0.001) respectively and the median serum MBL level was 1.53±1.87 mg/ml and 1.97±2.03 mg/ml (p=0.039) respectively. CRP (p<0.001) and MBL (p=0.042) were determined meaningful parameters for DERMATOPHYTOSIS. MBL deficiency (MBL concentrations <1 mg/ml) was higher in control subjects (56.2%) than in patients (41.0%). Conclusion: Findings of this study indicate increased concentrations of CRP and MBL in patients affected to DERMATOPHYTOSIS and their role in this infection. Probably observation of high frequency of MBL deficiency in healthy individuals in compare with patients group indicates that it is not predisposing factor in affecting to DERMATOPHYTOSIS.

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APA: Copy

NAMI, SANAM, FALAHATI, MEHRABAN, ZEINI, FARIDEH, AKHLAGHI, LAME, SADRI, MOHAMMAD, TABATABAIE, FATEMEH, GHASEMI, ZEINAB, & NOZARI, SHIMA. (2011). INVESTIGATION OF SERUM C-REACTIVE PROTEIN AND MANNOSE-BINDING LECTIN LEVELS IN PATIENTS WITH DERMATOPHYTOSIS. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 18(89), 46-53. SID. https://sid.ir/paper/10807/en

Vancouver: Copy

NAMI SANAM, FALAHATI MEHRABAN, ZEINI FARIDEH, AKHLAGHI LAME, SADRI MOHAMMAD, TABATABAIE FATEMEH, GHASEMI ZEINAB, NOZARI SHIMA. INVESTIGATION OF SERUM C-REACTIVE PROTEIN AND MANNOSE-BINDING LECTIN LEVELS IN PATIENTS WITH DERMATOPHYTOSIS. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2011;18(89):46-53. Available from: https://sid.ir/paper/10807/en

IEEE: Copy

SANAM NAMI, MEHRABAN FALAHATI, FARIDEH ZEINI, LAME AKHLAGHI, MOHAMMAD SADRI, FATEMEH TABATABAIE, ZEINAB GHASEMI, and SHIMA NOZARI, “INVESTIGATION OF SERUM C-REACTIVE PROTEIN AND MANNOSE-BINDING LECTIN LEVELS IN PATIENTS WITH DERMATOPHYTOSIS,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 18, no. 89, pp. 46–53, 2011, [Online]. Available: https://sid.ir/paper/10807/en

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