HER2/NEU AND αSMA EXPRESSION IN ORAL SQUAMOUS CELL CARCINOMA

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SEIFI S.; SHAFAIE SH.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES) Year:2011 | Volume:12 | Issue:1 (30) Page(s): 11-18

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Title

HER2/NEU AND αSMA EXPRESSION IN ORAL SQUAMOUS CELL CARCINOMA

Author(s)

SEIFI S. | SHAFAIE SH. | Issue Writer Certificate

Keywords

SQUAMOUS CELL CARCINOMAQ1

HER2/NEUQ1

αSMAQ1

MYOFIBROBLASTQ1

Abstract

Statement of Problem: SQUAMOUS CELL CARCINOMA (SCC) is the most common cancer of the mouth, but its pathogenesis is unknown. HER2/NEU is a protoncogene with homologue sequence with EGF. aSMA is a smooth muscle specific actin which indicates the existence of MYOFIBROBLASTs in the oral cancer stroma. Purpose: This study aimed to measure the frequency of HER2/NEU and (alpha) aSMA in oral SCC. Materials and Method: For this study, 18 paraffinized blocks of OSCC were immunostained with Anti HER2/NEU, Anti (Alpha) SMA. Percentage and degree of the epithelial cells staining and percentage staining of MYOFIBROBLASTs were considered. The results of the study were analyzed using kappa and X2.Results: From 18 cases of OSCC, 3 and 12 cases were positive with HER2/NEU and aSMA, respectively. In the normal oral mucosa, one case was positive (Score 2) with HER2/NEU but aSMA positive MYOFIBROBLASTs were not seen in the stroma of OSCC. A significant difference was seen in aSMA expression in OSCC and the normal oral mucosa (p=0.002). No significant difference was found in HER2/NEU expression in OSCC and normal mucosa (p>0.05).Conclusion: The results of this study suggest that aSMA has an effective role in pathogenesis and aggressive behavior of OSCC but HER2/NEU has no main role in this type of oral cancer.

Cites

IMMUNOHISTOCHEMICAL EVALUATION OF HER2/NEU PROTOONCOGENE IN SQUAMOUS CELL CARCINOMA, AND DYSPLASTIC AND NORMAL MUCOSA IN THE ORAL CAVITY

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APA: Copy

SEIFI, S., & SHAFAIE, SH.. (2011). HER2/NEU AND αSMA EXPRESSION IN ORAL SQUAMOUS CELL CARCINOMA. JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES), 12(1 (30)), 11-18. SID. https://sid.ir/paper/108355/en

Vancouver: Copy

SEIFI S., SHAFAIE SH.. HER2/NEU AND αSMA EXPRESSION IN ORAL SQUAMOUS CELL CARCINOMA. JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2011;12(1 (30)):11-18. Available from: https://sid.ir/paper/108355/en

IEEE: Copy

S. SEIFI, and SH. SHAFAIE, “HER2/NEU AND αSMA EXPRESSION IN ORAL SQUAMOUS CELL CARCINOMA,” JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES), vol. 12, no. 1 (30), pp. 11–18, 2011, [Online]. Available: https://sid.ir/paper/108355/en

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