Investigating the effect of telmisartan on acrylamide-induced neurotoxicity through in vitro and in vivo methods

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Yazdanpanah Zahra; Ghasemzadeh Rahbardar Mahboobeh; RAZAVI BIBI MARJAN; HOSSEINZADEH HOSSEIN

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Journal Paper

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Journal: Iranian Journal of Basic Medical Sciences Year:2023 | Volume:26 | Issue:9 Page(s): 1024-1029

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Title

Investigating the effect of telmisartan on acrylamide-induced neurotoxicity through in vitro and in vivo methods

Author(s)

Yazdanpanah Zahra | Ghasemzadeh Rahbardar Mahboobeh | RAZAVI BIBI MARJAN | HOSSEINZADEH HOSSEIN | Issue Writer Certificate

Keywords

Anti-oxidants

Cell survival

Motor disorders

Neurotoxins

PC12 cells

Vitamin E

Abstract

Objective(s): Acrylamide (ACR) is an environmental contaminant and neurotoxin. Telmisartan is an AT1 blocker that has neuroprotective properties basically through its anti-oxidant effect. The effect of telmisartan on ACR-induced neurotoxicity was investigated in this study. Materials and Methods: Male Wistar rats were randomly assigned to eight groups (n=6): 1: Control (normal saline), 2: ACR (50 mg/kg, 11 days, IP), 3: ACR+Vitamin E (200 mg/kg, every other day, 11 days), 4-6: ACR+telmisartan (0. 6, 1. 25, and 2. 5 mg/kg, 11 days, IP), 7: ACR+telmisartan (0. 6 mg/kg, days 3–, 11), 8: Telmisartan (2. 5 mg/kg, 11 days). The behavioral test and blood pressure were assessed after 11 days. Then, the levels of MDA and GSH in brain tissue were measured. The MTT assay was used to evaluate the effect of telmisartan on ACR-induced cytotoxicity. Results: Exposing PC12 cells to ACR decreased cell viability versus the control group. Pretreating PC12 cells with telmisartan (0. 0125, 0. 025 µ, M) enhanced cell viability compared with the ACR group. Compared with control samples, ACR significantly caused motor impairment, elevated MDA, and reduced GSH levels. Locomotor abnormalities were significantly ameliorated by telmisartan (0. 6, 1. 25 mg/kg, 11 days) and Vitamin E versus the ACR group. Receiving telmisartan (0. 6, 1. 25, and 2. 5 mg/kg) and Vitamin E along with ACR decreased MDA levels and enhanced GSH content compared with the ACR group. There was no significant difference in animal blood pressure between the groups. Conclusion: Oxidative stress has a chief role in the neurotoxicity of ACR. Telmisartan (in doses that do not affect blood pressure) ameliorated ACR-induced toxicity by inhibiting oxidative stress.

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APA: Copy

Yazdanpanah, Zahra, Ghasemzadeh Rahbardar, Mahboobeh, RAZAVI, BIBI MARJAN, & HOSSEINZADEH, HOSSEIN. (2023). Investigating the effect of telmisartan on acrylamide-induced neurotoxicity through in vitro and in vivo methods. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 26(9), 1024-1029. SID. https://sid.ir/paper/1084659/en

Vancouver: Copy

Yazdanpanah Zahra, Ghasemzadeh Rahbardar Mahboobeh, RAZAVI BIBI MARJAN, HOSSEINZADEH HOSSEIN. Investigating the effect of telmisartan on acrylamide-induced neurotoxicity through in vitro and in vivo methods. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2023;26(9):1024-1029. Available from: https://sid.ir/paper/1084659/en

IEEE: Copy

Zahra Yazdanpanah, Mahboobeh Ghasemzadeh Rahbardar, BIBI MARJAN RAZAVI, and HOSSEIN HOSSEINZADEH, “Investigating the effect of telmisartan on acrylamide-induced neurotoxicity through in vitro and in vivo methods,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 26, no. 9, pp. 1024–1029, 2023, [Online]. Available: https://sid.ir/paper/1084659/en

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