Wharton’, s jelly mesenchymal stem cells attenuate global hypoxia-induced learning and memory impairment via preventing blood-brain barrier breakdown

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOKHTARI TAHMINEH; Shayan Maryam; Rezaei Rashnudi Amirmohammad; HASSANZADEH GHOLAMREZA; Mehran Nia Kobra

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2023 | Volume:26 | Issue:9 Page(s): 1053-1060

Download Full-Text

View:

Download:

Cites:

Information Journal Paper

Title

Wharton’, s jelly mesenchymal stem cells attenuate global hypoxia-induced learning and memory impairment via preventing blood-brain barrier breakdown

Author(s)

Keywords

Blood-brain barrier

Hippocampus

Hypoxia

Intraventricular

Mesenchymal stem cells

Wharton jelly

Abstract

Objective(s): Intracerebroventricular (ICV) injections of Mesenchymal stem cells (MSCs) may improve the function and structure of Blood-brain barrier (BBB), possibly by preserving the BBB integrity. This study examined the impact of Wharton’, s jelly (WJ)-MSCs on cognitive dysfunction and BBB disruption following a protracted hypoxic state. Materials and Methods: Twenty-four male Wistar rats were randomly studied in four groups: Control (Co): Healthy animals, Sham (Sh): Rats were placed in the cage without Hypoxia induction and with ICV injection of vehicle, Hypoxic (Hx)+vehicle: Hypoxic rats with ICV injection of vehicle (5 μ, l of PBS), and Hx+MSCs: Hypoxic rats with ICV injection of MSCs. Spatial learning and memory were evaluated one week after WJ-MSCs injection, and then animals were sacrificed for molecular research. Results: Hypoxia increased latency and lowered the time and distance required reaching the target quarter, according to the findings. Furthermore, hypoxic rats had lower gene expression and protein levels of Hippocampus vascular endothelial (VE)-cadherin, claudin 5, and tricellulin gene expression than Co and Sh animals (P<0. 05). Finally, administering WJ-MSCs after long-term Hypoxia effectively reversed the cognitive deficits and prevented the BBB breakdown via the upregulation of VE-cadherin, claudin 5, and tricellulin genes (P<0. 05). Conclusion: These findings suggest that prolonged Hypoxia induces spatial learning and memory dysfunction and increases BBB disruption, the potential mechanism of which might be via reducing VE-cadherin, claudin 5, and tricellulin genes. Hence, appropriate treatment with WJ-MSCs could reverse ischemia adverse effects and protect the BBB integrity following prolonged Hypoxia.

Cites

No record.

References

Cite

APA: Copy

Shayan, Maryam, Rezaei Rashnudi, Amirmohammad, HASSANZADEH, GHOLAMREZA, & Mehran Nia, Kobra. (2023). Wharton’, s jelly mesenchymal stem cells attenuate global hypoxia-induced learning and memory impairment via preventing blood-brain barrier breakdown. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 26(9), 1053-1060. SID. https://sid.ir/paper/1084669/en

Vancouver: Copy

Shayan Maryam, Rezaei Rashnudi Amirmohammad, HASSANZADEH GHOLAMREZA, Mehran Nia Kobra. Wharton’, s jelly mesenchymal stem cells attenuate global hypoxia-induced learning and memory impairment via preventing blood-brain barrier breakdown. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2023;26(9):1053-1060. Available from: https://sid.ir/paper/1084669/en

IEEE: Copy

Maryam Shayan, Amirmohammad Rezaei Rashnudi, GHOLAMREZA HASSANZADEH, and Kobra Mehran Nia, “Wharton’, s jelly mesenchymal stem cells attenuate global hypoxia-induced learning and memory impairment via preventing blood-brain barrier breakdown,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 26, no. 9, pp. 1053–1060, 2023, [Online]. Available: https://sid.ir/paper/1084669/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops