COMPARISON OF REACTIVE MESOTHELIAL AND METASTATIC ADENOCARCINOMA CELLS IN CONVENTIONAL AND CEA MONOCLONAL ANTIBODY STAINING

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AFSHAR MOGHADAM N.; MAHZOUNI P.; BARAKATEIN Z.

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Journal: Razi Journal of Medical Sciences Year:2005 | Volume:11 | Issue:43 Page(s): 711-716

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Information Journal Paper

Title

COMPARISON OF REACTIVE MESOTHELIAL AND METASTATIC ADENOCARCINOMA CELLS IN CONVENTIONAL AND CEA MONOCLONAL ANTIBODY STAINING

Author(s)

AFSHAR MOGHADAM N. | MAHZOUNI P. | BARAKATEIN Z. | Issue Writer Certificate

Keywords

REACTIVE MESOTHELIAL CELLSQ4

METASTATIC ADENOCARCINOMAQ4

CARCINOEMBRYONIC ANTIGEN (CEA)Q4

Abstract

Distinction between reactive mesothelial and METASTATIC ADENOCARCINOMA cells in serous fluids is very important and sometimes very difficult. CEA, which is a tumor marker, is positive in 50 to 80% of METASTATIC ADENOCARCINOMA and negative in REACTIVE MESOTHELIAL CELLS. In the present study, 85 samples of body serous fluid were selected and then referred to laboratory of Alzahra Hospital in Isfahan. Cell blocks were prepared from samples. Hematoxylin-Eosin and immunohistochemical staining with CEA monoclonal antibody was then performed. In simple morphology, negative, positive and suspicious samples were respectively 68.2%, 21.2% and 10.6%. In immunohistochemical staining with CEA monoclonal antibody, 94.8% of previous negative results in simple morphology was negative and 5.2% was positive. Of positive and suspicious samples, positive CEA results were 44.4% and 50%, respectively. According to this study, in samples that Hematoxylin-Eosin stain is negative and positive, immunohistochemical staining is not needed, because this method is expensive and not helpful in these samples and, therefore, is recommended for suspicious cases.

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APA: Copy

AFSHAR MOGHADAM, N., MAHZOUNI, P., & BARAKATEIN, Z.. (2005). COMPARISON OF REACTIVE MESOTHELIAL AND METASTATIC ADENOCARCINOMA CELLS IN CONVENTIONAL AND CEA MONOCLONAL ANTIBODY STAINING. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 11(43), 711-716. SID. https://sid.ir/paper/10879/en

Vancouver: Copy

AFSHAR MOGHADAM N., MAHZOUNI P., BARAKATEIN Z.. COMPARISON OF REACTIVE MESOTHELIAL AND METASTATIC ADENOCARCINOMA CELLS IN CONVENTIONAL AND CEA MONOCLONAL ANTIBODY STAINING. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2005;11(43):711-716. Available from: https://sid.ir/paper/10879/en

IEEE: Copy

N. AFSHAR MOGHADAM, P. MAHZOUNI, and Z. BARAKATEIN, “COMPARISON OF REACTIVE MESOTHELIAL AND METASTATIC ADENOCARCINOMA CELLS IN CONVENTIONAL AND CEA MONOCLONAL ANTIBODY STAINING,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 11, no. 43, pp. 711–716, 2005, [Online]. Available: https://sid.ir/paper/10879/en

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