Histopathological assesment of sargassum tenerrimum algae extract effect on the mice bone tissue with osteoporosis

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Javadi Azadeh sadat; HEYDARI NASRABADI MITRA; BAKHSHI KHANIKI GHOLAMREZA

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Journal: Razi Journal of Medical Sciences Year:2017 | Volume:24 | Issue:155 Page(s): 1-10

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Title

Histopathological assesment of sargassum tenerrimum algae extract effect on the mice bone tissue with osteoporosis

Author(s)

Javadi Azadeh sadat | HEYDARI NASRABADI MITRA | BAKHSHI KHANIKI GHOLAMREZA | Issue Writer Certificate

Keywords

OsteoporosisQ2

MouseQ2

Sargassum algaeQ1

HistopathologyQ2

Abstract

Background: Osteoporosis is a silent disease which is causing death of significant population due to bone fractures. Use of natural supplements is considered with respect to side effects of chemical drugs. In this study, the effect of Sargassum algae on Osteoporosis disease was investigated. Methods: The study was done on 80 mice heads of NMRI race. After Osteoporosis induction, the mice were divided into the control, sham, positive control, experimental and negative control groups. The therapeutic dose of positive control group was 125 mg/kg/day of calcium and 0. 025 μ g/week/mice vitamin D and that of in the experimental group was 10mg/100g (bw)/day Sargassum algae extract that was fed for 28 days to each group. Finally, Histopathology sections were studied. Results: The negative control group had more degradation in lamellar bone (bone blades) than other groups (P<0. 01). The experimental group had less degradation compared to negative control group and also, the number of observed osteoblasts in the periosteum had a significant increase than negative control group (P<0. 01). Conclusion: Our study showed that Sargassum tenerrimum algae has meaningful effect on Osteoporosis and since it includes active ingredients with absorbable calcium; it can have the ability of Osteoporosis inhibition in several ways. Also, it was shown that algae have unique effect in ossification process and inhibition of osteoclast production via activation of Smad and BMP path, RANK protein inhibition and TNFα .

Cites

Effects of Eucheuma Cottoni L Algae on COX2 and SOD genes in breast cancer tissue induced in Balb-C mice by Real-Time PCR

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APA: Copy

Javadi, Azadeh sadat, HEYDARI NASRABADI, MITRA, & BAKHSHI KHANIKI, GHOLAMREZA. (2017). Histopathological assesment of sargassum tenerrimum algae extract effect on the mice bone tissue with osteoporosis. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 24(155 ), 1-10. SID. https://sid.ir/paper/10935/en

Vancouver: Copy

Javadi Azadeh sadat, HEYDARI NASRABADI MITRA, BAKHSHI KHANIKI GHOLAMREZA. Histopathological assesment of sargassum tenerrimum algae extract effect on the mice bone tissue with osteoporosis. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2017;24(155 ):1-10. Available from: https://sid.ir/paper/10935/en

IEEE: Copy

Azadeh sadat Javadi, MITRA HEYDARI NASRABADI, and GHOLAMREZA BAKHSHI KHANIKI, “Histopathological assesment of sargassum tenerrimum algae extract effect on the mice bone tissue with osteoporosis,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 24, no. 155 , pp. 1–10, 2017, [Online]. Available: https://sid.ir/paper/10935/en

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