A review on regulation of autophagy by Reactive Oxygen Species (ROS)

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ZARRINGOL MINA

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Journal: Razi Journal of Medical Sciences Year:2018 | Volume:24 | Issue:164 Page(s): 93-105

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Information Journal Paper

Title

A review on regulation of autophagy by Reactive Oxygen Species (ROS)

Author(s)

ZARRINGOL MINA | Issue Writer Certificate

Keywords

AutophagyQ1

Reactive oxygen speciesQ2

AntioxidantsQ2

MitophagyQ1

Abstract

Reactive oxygen species (ROS) are small, short-lived and highly reactive molecules that can oxidize proteins, lipids and DNA. ROS are formed by incomplete one-electron reduction of oxygen. ROS include oxygen anions, free radicals, including superoxide and hydroxyl radicals, and peroxides such as hydrogen peroxide (H2O2). Autophagy is a catabolic pathway for degradation of intracellular proteins and organelles via the lysosome. Autophagy is activated under stress conditions such as starvation, ischemia/reperfusion and pathogen infection, and is deregulated in various pathological conditions, including cancer and neurodegenerative diseases. It is generally accepted that ROS induce Autophagy, and that Autophagy, in turn, serves to reduce oxidative damage. Cells have developed various nonenzymatic and enzymatic antioxidizing agents to detoxify ROS and prevent oxidative stress. These include glutathione, thioredoxin, superopxide dismutase (SOD), catalase and peroxidases. ROS produced by damaged mitochondria might induce Mitophagy, which in turn eliminates the damaged organelles. Two pathologies highly associated with the accumulation of ROS are cancer and ischemia/reperfusion. The role of mitochondria as ROS generators, is essential for the activation of Autophagy. Autophagy is a survival mechanism in response to ROS. Removal of damaged mitochondria and oxidized proteins, in most cases, supports survival.

Cites

The effects of adenosine injection after of brain ischemia reperfusion injury on gene expression of NF-kB/p65 and activity level of ROS in hippocampus tissue of male wistar rats

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APA: Copy

ZARRINGOL, MINA. (2018). A review on regulation of autophagy by Reactive Oxygen Species (ROS). RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 24(164 ), 93-105. SID. https://sid.ir/paper/11121/en

Vancouver: Copy

ZARRINGOL MINA. A review on regulation of autophagy by Reactive Oxygen Species (ROS). RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2018;24(164 ):93-105. Available from: https://sid.ir/paper/11121/en

IEEE: Copy

MINA ZARRINGOL, “A review on regulation of autophagy by Reactive Oxygen Species (ROS),” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 24, no. 164 , pp. 93–105, 2018, [Online]. Available: https://sid.ir/paper/11121/en

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