DETERMINATION OF EXPERIMENTAL TUMOR VOLUME OF A MOUSE USING OPTICAL IMAGING SYSTEM IN DIFFERENT PROCESSING STAGES

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HOSSEINI MALIHE SADAT; HEJAZI MARJANEH; HAJATI JAMSHID; HATMI ZEYNAB; MOHAMMADREZA HANIEH; NAJAF ZADE EBRAHIM; JAMALI AREZOU; POOR GHOLAMI NEJAD ARASH

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Journal: Lasers in Medicine Year:2011 | Volume:8 | Issue:1 (39) Page(s): 6-11

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Title

DETERMINATION OF EXPERIMENTAL TUMOR VOLUME OF A MOUSE USING OPTICAL IMAGING SYSTEM IN DIFFERENT PROCESSING STAGES

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Keywords

TUMOR VOLUMEQ3

OPTICAL IMAGINGQ2

BALB/C MOUSEQ3

FLUORESCEINQ3

WEHI-164 CELLSQ3

Abstract

Introduction: Fluorescence molecular imaging (FMI) in reflectance mode is a powerful method for providing valuable information about pathologic processes.Tumor growth is a common pathologic process which can be traditionally obtained by caliper measurement. The caliper measurement has several major disadvantages. However FMI method can be used as a non-invasibly method. The goal of this project is validating FMI of tumor growth by comparing it to traditional TUMOR VOLUME measurement method such as caliper measurement.Materials and methods: Here we used an animal tumor model to evaluate the extent on correlation between noninvasively measured fluorescence and traditional methods. BALB/c mice received subcutaneous injection of WEHI-164 CELLS. The tumor size was measured. FLUORESCEIN was directly injected in center of the tumor. Serial measurements of fluorescence intensities were performed with FMI. After imaging, the mice were sacrificed and tumor was removed for weighting.Results: The results showed that Spearman correlation coefficient between TUMOR VOLUME and the maximum height of fluorescent intensity in the first, the second and the third group are 0.019, 0.5 and 0.09 respectively. The ROC analysis showed that the cutoff point of TUMOR VOLUME and the weight are 93 mm3 and 0.12 g respectively.Discussion and ConclusionThe measurement of tumor growth in the BALB/c mice by imaging fluorescence correlates well with the traditional method of determining the TUMOR VOLUME and with the increase in tumor weight that results from tumor growth. Given the great advantages of measuring fluorescence intensity, we conclude that FMI imaging is a the reliable and superior method for measuring experimental tumor growth in the small animals.

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APA: Copy

HOSSEINI, MALIHE SADAT, HEJAZI, MARJANEH, HAJATI, JAMSHID, HATMI, ZEYNAB, MOHAMMADREZA, HANIEH, NAJAF ZADE, EBRAHIM, JAMALI, AREZOU, & POOR GHOLAMI NEJAD, ARASH. (2011). DETERMINATION OF EXPERIMENTAL TUMOR VOLUME OF A MOUSE USING OPTICAL IMAGING SYSTEM IN DIFFERENT PROCESSING STAGES. LASER IN MEDICINE, 8(1 (39)), 6-11. SID. https://sid.ir/paper/113503/en

Vancouver: Copy

HOSSEINI MALIHE SADAT, HEJAZI MARJANEH, HAJATI JAMSHID, HATMI ZEYNAB, MOHAMMADREZA HANIEH, NAJAF ZADE EBRAHIM, JAMALI AREZOU, POOR GHOLAMI NEJAD ARASH. DETERMINATION OF EXPERIMENTAL TUMOR VOLUME OF A MOUSE USING OPTICAL IMAGING SYSTEM IN DIFFERENT PROCESSING STAGES. LASER IN MEDICINE[Internet]. 2011;8(1 (39)):6-11. Available from: https://sid.ir/paper/113503/en

IEEE: Copy

MALIHE SADAT HOSSEINI, MARJANEH HEJAZI, JAMSHID HAJATI, ZEYNAB HATMI, HANIEH MOHAMMADREZA, EBRAHIM NAJAF ZADE, AREZOU JAMALI, and ARASH POOR GHOLAMI NEJAD, “DETERMINATION OF EXPERIMENTAL TUMOR VOLUME OF A MOUSE USING OPTICAL IMAGING SYSTEM IN DIFFERENT PROCESSING STAGES,” LASER IN MEDICINE, vol. 8, no. 1 (39), pp. 6–11, 2011, [Online]. Available: https://sid.ir/paper/113503/en

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