COMPARISON OF GENETIC SIMILARITY ESTIMATED USING PEDIGREE INFORMATION AND A LIMITED NUMBER OF MICROSATELLITE MARKERS

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MOHAMMADI Y.; GHANBARI S.; DARMANI KOUHI H.; SATAEI MOKHTARI M.; ESMAILIZADEH KASHKOUEIYEH A.

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Journal: MODERN GENETICS JOURNAL (MGJ) Year:2011 | Volume:6 | Issue:2 (25) Page(s): 71-82

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Title

COMPARISON OF GENETIC SIMILARITY ESTIMATED USING PEDIGREE INFORMATION AND A LIMITED NUMBER OF MICROSATELLITE MARKERS

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Keywords

AFSHARI SHEEPQ2

GENETIC SIMILARITYQ2

MICROSATELLITE MARKERQ2

Abstract

A comprehensive knowledge of the amount of genetic diversity in a breeding flock would allow better management and could improve the effectiveness of breeding program. The objectives of the present study were to estimate the level of GENETIC SIMILARITY in a breeding flock of AFSHARI SHEEP and to compare the performance of pedigree and DNA marker based methods for estimating pairwise genetic similarities. Genetic relationships among 95 animals were estimated using both MICROSATELLITE MARKERs and pedigree based data. A total of 102 polymorphic bands were obtained with 18 microsatellite primer pairs. Pedigree-based estimates of parent-offspring relationships and genotypic banding pattern were used to construct relatedness (a) and molecular coancestry (fM) matrices, respectively. The pedigree-based similarity (mean=0.032, range=0.00–0.75) was lower than the similarity assessed using MICROSATELLITE MARKERs (mean=0.36, range=0.10–0.83). Similarity estimates were used to construct dendrograms by using the Unweighted Pair-Group Method with Arithmetic Averages (UPGMA). The degree of relationship between the similarity matrices based on marker and pedigree data was measured by the normalized Mantel test. Even though there was a large difference between the means of the two similarity measures, a low positive correlation (r=0.22, p<0.01) was detected between the two similarity matrices. The observed low correlation between molecular vs., the pedigree based expected genetic similarities suggests that simple estimates of proportion of shared alleles using low density markers may not reflect the true proportions and it is preferable to use pedigree information whenever available.

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APA: Copy

MOHAMMADI, Y., GHANBARI, S., DARMANI KOUHI, H., SATAEI MOKHTARI, M., & ESMAILIZADEH KASHKOUEIYEH, A.. (2011). COMPARISON OF GENETIC SIMILARITY ESTIMATED USING PEDIGREE INFORMATION AND A LIMITED NUMBER OF MICROSATELLITE MARKERS. MODERN GENETICS JOURNAL (MGJ), 6(2 (25)), 71-82. SID. https://sid.ir/paper/116591/en

Vancouver: Copy

MOHAMMADI Y., GHANBARI S., DARMANI KOUHI H., SATAEI MOKHTARI M., ESMAILIZADEH KASHKOUEIYEH A.. COMPARISON OF GENETIC SIMILARITY ESTIMATED USING PEDIGREE INFORMATION AND A LIMITED NUMBER OF MICROSATELLITE MARKERS. MODERN GENETICS JOURNAL (MGJ)[Internet]. 2011;6(2 (25)):71-82. Available from: https://sid.ir/paper/116591/en

IEEE: Copy

Y. MOHAMMADI, S. GHANBARI, H. DARMANI KOUHI, M. SATAEI MOKHTARI, and A. ESMAILIZADEH KASHKOUEIYEH, “COMPARISON OF GENETIC SIMILARITY ESTIMATED USING PEDIGREE INFORMATION AND A LIMITED NUMBER OF MICROSATELLITE MARKERS,” MODERN GENETICS JOURNAL (MGJ), vol. 6, no. 2 (25), pp. 71–82, 2011, [Online]. Available: https://sid.ir/paper/116591/en

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