IN SILICO STUDIES OF SOME PHYTOCHEMICAL’S ANTI-ANGIOGENIC EFFECTS COMPARED TO SURAFENIB DRUG IN CANCER TREATMENT

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DEHGHANIAN F.; HOJATI Z.; KAY M.

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Journal: MODERN GENETICS JOURNAL (MGJ) Year:2015 | Volume:9 | Issue:4 (39) Page(s): 451-458

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Title

IN SILICO STUDIES OF SOME PHYTOCHEMICAL’S ANTI-ANGIOGENIC EFFECTS COMPARED TO SURAFENIB DRUG IN CANCER TREATMENT

Author(s)

DEHGHANIAN F. | HOJATI Z. | KAY M. | Issue Writer Certificate

Keywords

AANGIOGENESISQ2

CANCERQ2

PHYTOCHEMICALSQ2

SORAFENIBQ2

VEGFR2 RECEPTORQ2

Abstract

The vascular endothelial growth factor signaling pathway through VEGFR receptors is well known as one of the crucial regulators of angiogenesis. Deficiencies in angiogenesis regulation leading to neovascularization which is an essential process in solid tumor growth and metastasis. Inhibition of VEGFR2 tyrosine kinase receptor has been developed as a systemic treatment strategy for CANCER. SORAFENIB is one of the most important anti-angiogenic tyrosine kinase inhibitors, with high binding capacities to angiogenic kinases primarily VEGFR-2 were recently approved for treatment of patients with advanced CANCER. Two major problems have been noticed during the clinical development of angiogenesis inhibitors including significant clinical toxicities and drug resistance. To avoid such side effects, the natural compounds (phytochemicals) as VEGFR2 inhibitor in comparison with SORAFENIB are the best substitutes. Several offline tools, online tools and databases were used to obtain 3D structure of some PHYTOCHEMICALS, SORAFENIB and VEGFR2. Then, Docking studies of natural compounds and SORAFENIB with combination of VEGFR2 was down using Molegro Virtual Docker version 6. The study revealed Lutein, Homoharringtonine and Curcumin as potential drug compounds showing better binding efficiency and lower energy with VEGFR2 as target. Lutein, Homoharringtonine and curcumin require -172.5 Kcal/mol,-170 Kcal/mol and -165.3 Kcal/mol respectively and they were suggested as potential candidate PHYTOCHEMICALS for laboratory assessment.

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APA: Copy

DEHGHANIAN, F., HOJATI, Z., & KAY, M.. (2015). IN SILICO STUDIES OF SOME PHYTOCHEMICAL’S ANTI-ANGIOGENIC EFFECTS COMPARED TO SURAFENIB DRUG IN CANCER TREATMENT. MODERN GENETICS JOURNAL (MGJ), 9(4 (39)), 451-458. SID. https://sid.ir/paper/116687/en

Vancouver: Copy

DEHGHANIAN F., HOJATI Z., KAY M.. IN SILICO STUDIES OF SOME PHYTOCHEMICAL’S ANTI-ANGIOGENIC EFFECTS COMPARED TO SURAFENIB DRUG IN CANCER TREATMENT. MODERN GENETICS JOURNAL (MGJ)[Internet]. 2015;9(4 (39)):451-458. Available from: https://sid.ir/paper/116687/en

IEEE: Copy

F. DEHGHANIAN, Z. HOJATI, and M. KAY, “IN SILICO STUDIES OF SOME PHYTOCHEMICAL’S ANTI-ANGIOGENIC EFFECTS COMPARED TO SURAFENIB DRUG IN CANCER TREATMENT,” MODERN GENETICS JOURNAL (MGJ), vol. 9, no. 4 (39), pp. 451–458, 2015, [Online]. Available: https://sid.ir/paper/116687/en

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