Radiolabeling of gamma-irradiated rosmarinic acid by 67Gallium

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Damavandi Kamali N.; Rajabifar S.; Heidarieh M.

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ISSN: 2588-4824

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Paper Information

Journal: JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY Year:2024 | Volume:44 | Issue:4 Page(s): 163-169

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Title

Radiolabeling of gamma-irradiated rosmarinic acid by 67Gallium

Author(s)

Damavandi Kamali N. | Rajabifar S. | Heidarieh M. | Issue Writer Certificate

Keywords

Gallium-67Q4

RadiolabelingQ4

Rosmarinic acidQ4

Radiochemical PurityQ4

Abstract

Rosemary plant extract as a natural anti-oxidant is 4 times stronger than synthetic anti-oxidant like BHT and BHA. For this reason, it has been under attention not only for its anti-oxidant properties rather for its anti-inflammatory, anti-tumor, anti-bacterial, and anti-virus properties in different studies. This research investigates the effects of temperature, time, pH, and substance concentration in the labeling of irradiated Rosmarinic acid by radioisotope Gallium-67 as a high-resolution imaging agent for SPECT imaging. In this study, gamma irradiated Rosmarinic acid nanoparticles at 20 kGy and 30 kGy levels in two concentrations of 0.5 and 1% were radiolabeled by Gallium-67 radioisotope produced in Karaj cyclotron, and their efficiency and Radiochemical Purity were compared. Labeling conditions (including pH, temperature, time, and compound concentration) were investigated. Quality control was performed by thin-layer chromatography (RTLC). Resulting from the experiments, 30 kGy level and 1% concentration at 45 °C for 30 minutes at pH = 5.5-6 proved to be the best time for labeling rosemary nanoparticles, and the highest Radiochemical Purity achieved was 95%; radio conjugate also showed good stability after 12 hours.

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