Synthesis of 1-aryl 4-phenyl 1, 2, 3-triazols and Investigating Anti-Fungal and Anti-Bacterial Activity in In Vitro Conditions

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Zarenezhad Elham; Ghasemian Abdolmajid; Iraji Aida; Rostami chijan Mahsa; Kazemi Maryam; Haghjoo Elham

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Journal Paper

Paper Information

Journal: Medical Sciences Journal of Islamic Azad University,Tehran Medical Branch Year:2024 | Volume:34 | Issue:1 Page(s): 46-55

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Title

Synthesis of 1-aryl 4-phenyl 1, 2, 3-triazols and Investigating Anti-Fungal and Anti-Bacterial Activity in In Vitro Conditions

Author(s)

Keywords

AzolesQ4

Antimicrrobial activityQ4

Biological activityQ4

Abstract

Background: 3, 2, 1 triAzoles are an important class of five-membered heterocyclic compounds whose unique biological properties have made them an important class of chemical compounds. The Biological activity of these compounds is known as anti-fungal, anti-bacterial, anti-tumor, anti-inflammatory, anti-depressant, anti-tuberculosis, anti-HIV, etc. Materials and methods: In this research, first we synthesized new courcomin catalyst. We investigated synthesis of some 1, 2, 3 triazol derivatives and evaluated their anti-bacterial and anti-fungal effects. After synthesis and purification of some 1, 2, 3-triazol compound, the inhibitory effect of compounds against fungal (Candida albicans, Aspergillus niger) and against bacterial (Staphylococcus arueus and Escherichia coli) was evaluated. Results: It was found that compound (3): 1-(4-bromobenzyl)-1H-1, 2, 3-triazol-4-ol exhibited the best antifungal activities. Also this compound showed good activity against Staphylococcus areus as a Gram-positive bacteria. Conclusion: According to the results, it seems that the use of recombinant substance 3 as a new compound with acceptable antimicrobial properties can be considered

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