ALLELES OF HLA-DRB1 IN IRANIAN CHILDREN WITH JUVENILE RHEUMATOID ARTHRITIS

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FARIVAR SHIRIN; HADI ELHAM; SHIARI REZA

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Journal: GENETICS IN THE 3RD MILLENNIUM Year:2011 | Volume:8 | Issue:4 Page(s): 2151-2154

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Information Journal Paper

Title

ALLELES OF HLA-DRB1 IN IRANIAN CHILDREN WITH JUVENILE RHEUMATOID ARTHRITIS

Author(s)

FARIVAR SHIRIN | HADI ELHAM | SHIARI REZA | Issue Writer Certificate

Keywords

HLA-DRB1Q3

ARTHRITISQ3

JUVENILE RHEUMATOIDQ3

OLIGOARTHRITISQ3

NEGATIVE RHEUMATOID FACTORQ3

Abstract

This study was conducted on Iranian children with OLIGOARTHRITIS subtype of JUVENILE RHEUMATOID ARTHRITIS to determine the association of HLA-DRB1 alleles in Iran. HLA-DRB1 alleles were investigated in 33 Iranian children with OLIGOARTHRITIS JUVENILE RHEUMATOID ARTHRITIS and compared with 45 healthy controls. HLA typing was performed by PCR with sequence specific primers in either two groups and followed by direct detection of HLA polymorphism by sequence analysis in patients group. HLA-DRB1 11 was found to be the most frequent allele associated with NEGATIVE RHEUMATOID FACTOR OLIGOARTHRITIS JUVENILE RHEUMATOID ARTHRITIS in Iran, followed by HLA-DRB1 08. The frequency of HLA-DRB1 04 and 13 were not significantly different between the two groups. It could be concluded that there was a significant difference in allele frequencies between patients and controls that might help with predicting the susceptibility to OLIGOARTHRITIS JUVENILE RHEUMATOID ARTHRITIS.

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APA: Copy

FARIVAR, SHIRIN, HADI, ELHAM, & SHIARI, REZA. (2011). ALLELES OF HLA-DRB1 IN IRANIAN CHILDREN WITH JUVENILE RHEUMATOID ARTHRITIS. GENETICS IN THE 3RD MILLENNIUM, 8(4), 2151-2154. SID. https://sid.ir/paper/117201/en

Vancouver: Copy

FARIVAR SHIRIN, HADI ELHAM, SHIARI REZA. ALLELES OF HLA-DRB1 IN IRANIAN CHILDREN WITH JUVENILE RHEUMATOID ARTHRITIS. GENETICS IN THE 3RD MILLENNIUM[Internet]. 2011;8(4):2151-2154. Available from: https://sid.ir/paper/117201/en

IEEE: Copy

SHIRIN FARIVAR, ELHAM HADI, and REZA SHIARI, “ALLELES OF HLA-DRB1 IN IRANIAN CHILDREN WITH JUVENILE RHEUMATOID ARTHRITIS,” GENETICS IN THE 3RD MILLENNIUM, vol. 8, no. 4, pp. 2151–2154, 2011, [Online]. Available: https://sid.ir/paper/117201/en

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