THE ROLE OF ARC GENE IN MEMORY

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ZAREI BAHARE; ESMAEILI ABOLGHASEM; MOSHTAGHIYAN SEYED JAMAL; HABIBIYAN SAEED

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Journal: GENETICS IN THE 3RD MILLENNIUM Year:2010 | Volume:8 | Issue:3 Page(s): 2106-2111

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Title

THE ROLE OF ARC GENE IN MEMORY

Author(s)

ZAREI BAHARE | ESMAEILI ABOLGHASEM | MOSHTAGHIYAN SEYED JAMAL | HABIBIYAN SAEED | Issue Writer Certificate

Keywords

MEMORYQ3

POST-SYMPATIC DENSITYQ3

GYRUS HIPPOCAMPDQ3

ARCQ3

Abstract

Brain MEMORY storage and information processing occurs through changes in synaptic connections between neurons or synaptic plasticity. In experimental models of synaptic plasticity such as LTP, stabilization of these changes requires de novo protein synthesis. Immediately after stimulations that induce LTP or behavioral experiments which contribute to Long Term MEMORY (LTM) formation, Immediate-Early Genes are induced in hippocampal neurons, among neuronal activity dependent IEGs, ARC is of particular importance. ARC is robustly induced by plasticity-producing stimulation and is specifically targeted to stimulated synaptic areas. It also plays a critical role in the maintenance of long term potentiation and in MEMORY consolidation processes. Inhibition of ARC protein expression in the rat hippocampus, through ODNs infusion, impairs maintenance of LTP and consolidation of LTM. Thus, ARC appears to play a fundamental role in stabilization of activity-dependent hippocampal plasticity. In this paper, the role of ARC in MEMORY formation is discussed.

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APA: Copy

ZAREI, BAHARE, ESMAEILI, ABOLGHASEM, MOSHTAGHIYAN, SEYED JAMAL, & HABIBIYAN, SAEED. (2010). THE ROLE OF ARC GENE IN MEMORY. GENETICS IN THE 3RD MILLENNIUM, 8(3), 2106-2111. SID. https://sid.ir/paper/117219/en

Vancouver: Copy

ZAREI BAHARE, ESMAEILI ABOLGHASEM, MOSHTAGHIYAN SEYED JAMAL, HABIBIYAN SAEED. THE ROLE OF ARC GENE IN MEMORY. GENETICS IN THE 3RD MILLENNIUM[Internet]. 2010;8(3):2106-2111. Available from: https://sid.ir/paper/117219/en

IEEE: Copy

BAHARE ZAREI, ABOLGHASEM ESMAEILI, SEYED JAMAL MOSHTAGHIYAN, and SAEED HABIBIYAN, “THE ROLE OF ARC GENE IN MEMORY,” GENETICS IN THE 3RD MILLENNIUM, vol. 8, no. 3, pp. 2106–2111, 2010, [Online]. Available: https://sid.ir/paper/117219/en

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