NEW MUTATIONS IN 22 MITOCHONDRIAL TRNA GENES IN ALZHEIMER'S DISEASE

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SHEYBANINIA SAMIRA; AZADFAR PARISA; AKBARI LEILA; ASSARZADEGAN FARHAD; HOUSHMAND SEYED MASOUD

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Journal: GENETICS IN THE 3RD MILLENNIUM Year:2011 | Volume:9 | Issue:2 Page(s): 2367-2372

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Title

NEW MUTATIONS IN 22 MITOCHONDRIAL TRNA GENES IN ALZHEIMER'S DISEASE

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Keywords

DNAQ2

MITOCHONDRIALQ2

ALZHEIMER DISEASEQ2

RNAQ2

TRANSFERQ2

A12308GQ2

Abstract

Alzheimer’s Disease (AD) is the most common form of dementia in the elderly in which an interplay between genes and the environment is supposed to be involved. Mutations in MITOCHONDRIAL DNA (mtDNA) have been suspected to be causally related since MITOCHONDRIAL DNA is maternally inherited in a non-Mendelian way. All MITOCHONDRIAL tRNA genes of 24 AD patients and 50 healthy controls were investigated by sequencing method. Fifteen variations were found in different MITOCHONDRIAL tRNA genes. Eleven variations were polymorphic mutations. Four variations {C1631A, T1633A (tRNA Val), T14704C and T14723C (tRNA Glu)} filled the criteria for pathogenicity of mutation because of their: a) heteroplasmic state, b) conserved nucleotide, c) absence in the literature and d) absence in healthy controls. A12308G polymorphic mutation (tRNA Leu (CUN)) was found in 8 patients. This mutation has been reported in different neurodegenerative diseases as well as controls. We believe that these variations may have pathogenic effects in AD or have secondary effects in the disease process. The percentage of hetroplasmy may play a role in signs/symptoms or onset age of the disease.

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APA: Copy

SHEYBANINIA, SAMIRA, AZADFAR, PARISA, AKBARI, LEILA, ASSARZADEGAN, FARHAD, & HOUSHMAND, SEYED MASOUD. (2011). NEW MUTATIONS IN 22 MITOCHONDRIAL TRNA GENES IN ALZHEIMER'S DISEASE. GENETICS IN THE 3RD MILLENNIUM, 9(2), 2367-2372. SID. https://sid.ir/paper/117232/en

Vancouver: Copy

SHEYBANINIA SAMIRA, AZADFAR PARISA, AKBARI LEILA, ASSARZADEGAN FARHAD, HOUSHMAND SEYED MASOUD. NEW MUTATIONS IN 22 MITOCHONDRIAL TRNA GENES IN ALZHEIMER'S DISEASE. GENETICS IN THE 3RD MILLENNIUM[Internet]. 2011;9(2):2367-2372. Available from: https://sid.ir/paper/117232/en

IEEE: Copy

SAMIRA SHEYBANINIA, PARISA AZADFAR, LEILA AKBARI, FARHAD ASSARZADEGAN, and SEYED MASOUD HOUSHMAND, “NEW MUTATIONS IN 22 MITOCHONDRIAL TRNA GENES IN ALZHEIMER'S DISEASE,” GENETICS IN THE 3RD MILLENNIUM, vol. 9, no. 2, pp. 2367–2372, 2011, [Online]. Available: https://sid.ir/paper/117232/en

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