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Information Journal Paper

Title

VIRULENCE ASSESSMENT OF A NEOSPORA CANINUM ISOLATE FOR INBRED C57BL/6 MOUSE

Pages

  57-61

Abstract

NEOSPORA CANINUM (N. caninum) is an apicomplexan parasite and causes abortion and congenital neosporosis in cattle worldwide. In this study, we evaluate the virulence of a N. caninum isolate on mouse strain C57BL/6. Six groups of five mice C57BL/6 were intraperitoneally inoculated with 1x107, 1.5x 107, 2x 107, 3x107 and 4x107 tachyzoites and a control inoculum of DMEM, respectively. Clinical signs and mortality rate were recorded and confirmed by histopathological findings and molecular method. The results of this study indicated that LD50 was 2.5x107 tachyzoites of N. caninum per C57BL/6 mouse. This can be used as a lethal challenge model in vaccine development studies.

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    APA: Copy

    KARGAR, M., SAYARI, M., NAMAVARI, M., LOTFI, M., & KAMALZADEH, M.. (2012). VIRULENCE ASSESSMENT OF A NEOSPORA CANINUM ISOLATE FOR INBRED C57BL/6 MOUSE. ARCHIVES OF RAZI INSTITUTE, 67(1), 57-61. SID. https://sid.ir/paper/120043/en

    Vancouver: Copy

    KARGAR M., SAYARI M., NAMAVARI M., LOTFI M., KAMALZADEH M.. VIRULENCE ASSESSMENT OF A NEOSPORA CANINUM ISOLATE FOR INBRED C57BL/6 MOUSE. ARCHIVES OF RAZI INSTITUTE[Internet]. 2012;67(1):57-61. Available from: https://sid.ir/paper/120043/en

    IEEE: Copy

    M. KARGAR, M. SAYARI, M. NAMAVARI, M. LOTFI, and M. KAMALZADEH, “VIRULENCE ASSESSMENT OF A NEOSPORA CANINUM ISOLATE FOR INBRED C57BL/6 MOUSE,” ARCHIVES OF RAZI INSTITUTE, vol. 67, no. 1, pp. 57–61, 2012, [Online]. Available: https://sid.ir/paper/120043/en

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