EFFECT OF VITAMIN A, C AND ZINC SUPPLEMENTATIONS ON OXIDANT-ANTIOXIDANT AND CLINICAL INDICES IN RHEUMATOID ARTHRITIS PATIENTS: A RANDOMIZED CONTROL TRIAL

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ATHARI NIKAZAM S.; VAFA M.R.; NOURMOHAMMADI I.; BIDARI A.; HOUSHYARRAD A.; JAZAYERI SHIMA; HOSSEINI FATEMEH; FASIHI RADMANDI S.M.

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Journal: Iranian Journal of Epidemiology Year:2009 | Volume:5 | Issue:3 Page(s): 14-21

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Title

EFFECT OF VITAMIN A, C AND ZINC SUPPLEMENTATIONS ON OXIDANT-ANTIOXIDANT AND CLINICAL INDICES IN RHEUMATOID ARTHRITIS PATIENTS: A RANDOMIZED CONTROL TRIAL

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RHEUMATOID ARTHRITISQ3

OXIDATIVE STRESSQ2

ANTIOXIDANTSQ2

Abstract

Background & Objectives: oxygen free radicals have been implicated as mediators of tissue damage in RA patients. This study was aimed to find the effects of vitamin A, C and zinc supplementations on oxidant–antioxidant, inflammatory and clinical indices in inactive RA patients. Methods: We designed a randomized controlled trial. Forty nine (49) patients were randomly allocated in two groups; group I received their conventional treatment plus 300 mg vitamin C, 5 mg Zinc daily and 25000 IU vitamin A every other day for 12 weeks, group II received their conventional treatment only for the same duration. Disease activity (using the RHEUMATOID ARTHRITIS disease activity index (RADAI) score), biochemical indices [malondialdehyde (MDA), total antioxidant capacity (TAC)] and inflammatory markers [erythrocyte sedimentation rate (ESR), C - reactive protein (CRP)] was evaluated before and after 12 weeks.Results: Serum concentration of MDA and RADAI score (P<0.0001) and ESR (P=0.033) were significantly decreased and TAC levels (P<0.0001) were significantly increased in the first group in comparison to second group after 12 weeks. However, there were no statistically significant differences in serum CRP concentration of two groups (P>0.05). Conclusions: This study indicates that adding ANTIOXIDANTS as supplementations with conventional medications in inactive RA patients plays an important role in improving OXIDATIVE STRESS and decreasing disease activity and inflammatory status.

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APA: Copy

ATHARI NIKAZAM, S., VAFA, M.R., NOURMOHAMMADI, I., BIDARI, A., HOUSHYARRAD, A., JAZAYERI, SHIMA, HOSSEINI, FATEMEH, & FASIHI RADMANDI, S.M.. (2009). EFFECT OF VITAMIN A, C AND ZINC SUPPLEMENTATIONS ON OXIDANT-ANTIOXIDANT AND CLINICAL INDICES IN RHEUMATOID ARTHRITIS PATIENTS: A RANDOMIZED CONTROL TRIAL. IRANIAN JOURNAL OF EPIDEMIOLOGY, 5(3), 14-21. SID. https://sid.ir/paper/120518/en

Vancouver: Copy

ATHARI NIKAZAM S., VAFA M.R., NOURMOHAMMADI I., BIDARI A., HOUSHYARRAD A., JAZAYERI SHIMA, HOSSEINI FATEMEH, FASIHI RADMANDI S.M.. EFFECT OF VITAMIN A, C AND ZINC SUPPLEMENTATIONS ON OXIDANT-ANTIOXIDANT AND CLINICAL INDICES IN RHEUMATOID ARTHRITIS PATIENTS: A RANDOMIZED CONTROL TRIAL. IRANIAN JOURNAL OF EPIDEMIOLOGY[Internet]. 2009;5(3):14-21. Available from: https://sid.ir/paper/120518/en

IEEE: Copy

S. ATHARI NIKAZAM, M.R. VAFA, I. NOURMOHAMMADI, A. BIDARI, A. HOUSHYARRAD, SHIMA JAZAYERI, FATEMEH HOSSEINI, and S.M. FASIHI RADMANDI, “EFFECT OF VITAMIN A, C AND ZINC SUPPLEMENTATIONS ON OXIDANT-ANTIOXIDANT AND CLINICAL INDICES IN RHEUMATOID ARTHRITIS PATIENTS: A RANDOMIZED CONTROL TRIAL,” IRANIAN JOURNAL OF EPIDEMIOLOGY, vol. 5, no. 3, pp. 14–21, 2009, [Online]. Available: https://sid.ir/paper/120518/en

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