USING LATENT VARIABLES TO ELIMINATE MULTICOLLINEARITY EFFECT IN A LOGISTIC REGRESSION ON RISK FACTORS FOR BREAST CANCER

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POURHOSSEIN GHOLI M.A.; MEHRABI YAD ELAH; ALAVI MAJD HAMID; YAVARI P.

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Journal: Iranian Journal of Epidemiology Year:2006 | Volume:1 | Issue:2 Page(s): 41-45

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Title

USING LATENT VARIABLES TO ELIMINATE MULTICOLLINEARITY EFFECT IN A LOGISTIC REGRESSION ON RISK FACTORS FOR BREAST CANCER

Author(s)

POURHOSSEIN GHOLI M.A. | MEHRABI YAD ELAH | ALAVI MAJD HAMID | YAVARI P. | Issue Writer Certificate

Keywords

MULTICOLLINEARITYQ4

LATENT VARIABLESQ4

FACTOR ANALYSISQ2

PRINCIPAL COMPONENTS ANALYSISQ4

LOGISTIC REGRESSIONQ2

BREAST CANCERQ2

Abstract

Background and Objectives: LOGISTIC REGRESSION is one of the most widely used generalized linear models for analysis of the relationships between one or more explanatory variables and a categorical response. Strong correlations among explanatory variables (MULTICOLLINEARITY) reduce the efficiency of model to a considerable degree. In this study we used LATENT VARIABLES to reduce the effects of MULTICOLLINEARITY in the analysis of a case-control study.Methods: Our data came from a case-control study in which 300 women with BREAST CANCER were compared to 300 controls. Five highly correlated quantitative variables were selected to assess the effect of MULTICOLLINEARITY. First, an ordinary LOGISTIC REGRESSION model was fitted to the data. Then, to remove the effect of MULTICOLLINEARITY, two LATENT VARIABLES were generated using FACTOR ANALYSIS and PRINCIPAL COMPONENTS ANALYSIS methods. Parameters of LOGISTIC REGRESSION were estimated using these latent as explanatory variables. We used the estimated standard errors of the parameters to compare the efficiency of models.Results: The LOGISTIC REGRESSION based on five primary variables produced unusual odds ratio estimates for age at first pregnancy (OR=67960, 95%CI: 10184-453503) and for total length of breast feeding (OR=0). On the other hand, the parameters estimated for LOGISTIC REGRESSION on LATENT VARIABLES generated by both FACTOR ANALYSIS and PRINCIPAL COMPONENTS ANALYSIS were statistically significant (P<0.003). The standard errors were smaller than with ordinary LOGISTIC REGRESSION on original variables. The factors and components generated by the two methods explained at least 85% of the total variance.Conclusions: This research showed that the standard errors of the estimated parameters in LOGISTIC REGRESSION based on LATENT VARIABLES were considerably smaller than that of model for original variables. Therefore models including LATENT VARIABLES could be more efficient when there is MULTICOLLINEARITY among the risk factors for BREAST CANCER.

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APA: Copy

POURHOSSEIN GHOLI, M.A., MEHRABI, YAD ELAH, ALAVI MAJD, HAMID, & YAVARI, P.. (2006). USING LATENT VARIABLES TO ELIMINATE MULTICOLLINEARITY EFFECT IN A LOGISTIC REGRESSION ON RISK FACTORS FOR BREAST CANCER. IRANIAN JOURNAL OF EPIDEMIOLOGY, 1(2), 41-45. SID. https://sid.ir/paper/120635/en

Vancouver: Copy

POURHOSSEIN GHOLI M.A., MEHRABI YAD ELAH, ALAVI MAJD HAMID, YAVARI P.. USING LATENT VARIABLES TO ELIMINATE MULTICOLLINEARITY EFFECT IN A LOGISTIC REGRESSION ON RISK FACTORS FOR BREAST CANCER. IRANIAN JOURNAL OF EPIDEMIOLOGY[Internet]. 2006;1(2):41-45. Available from: https://sid.ir/paper/120635/en

IEEE: Copy

M.A. POURHOSSEIN GHOLI, YAD ELAH MEHRABI, HAMID ALAVI MAJD, and P. YAVARI, “USING LATENT VARIABLES TO ELIMINATE MULTICOLLINEARITY EFFECT IN A LOGISTIC REGRESSION ON RISK FACTORS FOR BREAST CANCER,” IRANIAN JOURNAL OF EPIDEMIOLOGY, vol. 1, no. 2, pp. 41–45, 2006, [Online]. Available: https://sid.ir/paper/120635/en

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