EFFECT OF TRANSFORMING GROWTH FACTOR-β (TGF--β) ON PROLIFERATION OF GASTRIC EPITHELIAL CELLS IN CULTURE

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GHAINI M.H.; GHAZANFARI T.; FALAH NADER

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Journal: IRANIAN JOURNAL OF PATHOLOGY (IJP) Year:2006 | Volume:1 | Issue:1 Page(s): 25-30

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Title

EFFECT OF TRANSFORMING GROWTH FACTOR-β (TGF--β) ON PROLIFERATION OF GASTRIC EPITHELIAL CELLS IN CULTURE

Author(s)

GHAINI M.H. | GHAZANFARI T. | FALAH NADER | Issue Writer Certificate

Keywords

TGF-βQ1

GASTRIC EPITHELIAL CELLSQ1

Abstract

Objective: Helicobacter pylori have a well-established role in the development of gastric cancer. In vitro studies reveal increased proliferation of the gastric mucosa in the presence of H. pylori infection. It has been also shown that production of some cytokines, such as interleukin-1 beta (IL-1b) is increased in H. pylori infection. In addition, IL-1b increases proliferation of gastric epithelial cell in culture study. In this study, the effect of transforming growth factor beta (TGF-b) on gastric epithelial cell proliferation has been examined. Materials and methods: AGS cells were cultured with TGF-b. DNA synthesis was evaluated by bromo-deoxyuridine (BrdU) test and total viable cell numbers by MTT assay. Results: TGF-b decreased DNA synthesis and cell numbers. This effect was both time and dose-dependent (p<0.05). Both tests, BrdU test & MTT assay revealed this suppressive effect, but it was more evident in BrdU test.Conclusion: TGF-b suppresses proliferation of malignant GASTRIC EPITHELIAL CELLS. It appears that modulatin of tyrosine kinase activity is essential to anti-proliferative effect of TGF-b. Decreased gastric epithelial proliferation due to TGF-b may contribute to the decreased risk of gastric cancer and precancerous lesions in H. pylori-infected individuals or slowing the progression of disease in gastric cancer patients.

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APA: Copy

GHAINI, M.H., GHAZANFARI, T., & FALAH, NADER. (2006). EFFECT OF TRANSFORMING GROWTH FACTOR-β (TGF--β) ON PROLIFERATION OF GASTRIC EPITHELIAL CELLS IN CULTURE. IRANIAN JOURNAL OF PATHOLOGY (IJP), 1(1), 25-30. SID. https://sid.ir/paper/123834/en

Vancouver: Copy

GHAINI M.H., GHAZANFARI T., FALAH NADER. EFFECT OF TRANSFORMING GROWTH FACTOR-β (TGF--β) ON PROLIFERATION OF GASTRIC EPITHELIAL CELLS IN CULTURE. IRANIAN JOURNAL OF PATHOLOGY (IJP)[Internet]. 2006;1(1):25-30. Available from: https://sid.ir/paper/123834/en

IEEE: Copy

M.H. GHAINI, T. GHAZANFARI, and NADER FALAH, “EFFECT OF TRANSFORMING GROWTH FACTOR-β (TGF--β) ON PROLIFERATION OF GASTRIC EPITHELIAL CELLS IN CULTURE,” IRANIAN JOURNAL OF PATHOLOGY (IJP), vol. 1, no. 1, pp. 25–30, 2006, [Online]. Available: https://sid.ir/paper/123834/en

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