A STUDY ON THE EFFECTIVENESS OF ATORVASTATIN IN THE TREATMENT OF ERECTILE DYSFUNCTION IN HYPERCHOLESTEROLEMIC MEN

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DADFAR M.R.; TAEI KARIM; EBRAHIMPOUR ABOU TALEB

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Journal: Jundishapur Scientific Medical Journal Year:2008 | Volume:7 | Issue:1 (56) Page(s): 106-112

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Title

A STUDY ON THE EFFECTIVENESS OF ATORVASTATIN IN THE TREATMENT OF ERECTILE DYSFUNCTION IN HYPERCHOLESTEROLEMIC MEN

Author(s)

DADFAR M.R. | TAEI KARIM | EBRAHIMPOUR ABOU TALEB | Issue Writer Certificate

Keywords

ERECTILE DYSFUNCTIONQ3

IMPOTENCEQ3

HYPERCHOLESTEROLEMIAQ3

ATORVASTATINQ3

Abstract

Objective: HYPERCHOLESTEROLEMIA is a known risk factor for ERECTILE DYSFUNCTION (ED). Lipid lowering agents may improve ED in hypercholesterolemicmen. The aim of the present study was to evaluate the effects of lipid lowering agent ATORVASTATIN in treatment of ED in hypercholesterolemic men.Subjects and Methods: In this prospective controlled clinical trials a total of 11 hypercholesterolemic men with ED were enrolled the study. They were treated with ATORVASTATIN (20 mg once daily for a period 4 months). All the patients were evaluated by history, clinical interview, physical examination and laboratory analysis both at the beginning and end of the study. International index of erectile function (IIEF) questionnaire and nocturnal penile tumescence testing rigidity (NPTR) tests were also performed for each patient, prior to and after the study.Results: Eleven patient were entered the study with a mean age of 54±3 years, of whom 10 patients completed the study. Low density lipoprotein (LDL) decreased in a statistically significant manner after treatment period (mean difference= 39.1%, P< 0.005) in all of the patients. All the patient reported subjective improvement in erectile function (P<0.001), IIEF questionnaire showed significant changes in total erectile function and sexual performance (mean difference= +4.7, 95 % Cl 2-8-6.2, P< 0.001). NPTR test showed statistically significant improvement in rigidity activity units (RAU) in the basal area of penis (P<0.001). A significant statistical relation was recorded between improvement in erectile function and lipid lowering effect of ATORVASTATIN (P< 0.005).Conclusion: The lipid lowering agent ATORVASTATIN has a dual favourable effect in treating both HYPERCHOLESTEROLEMIA and ERECTILE DYSFUNCTION. Better sexual performance can elevate both the sense of well being and quality of life in these men, more extended and multicentre studies need be designed to evaluate this effect.

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APA: Copy

DADFAR, M.R., TAEI, KARIM, & EBRAHIMPOUR, ABOU TALEB. (2008). A STUDY ON THE EFFECTIVENESS OF ATORVASTATIN IN THE TREATMENT OF ERECTILE DYSFUNCTION IN HYPERCHOLESTEROLEMIC MEN. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 7(1 (56)), 106-112. SID. https://sid.ir/paper/12526/en

Vancouver: Copy

DADFAR M.R., TAEI KARIM, EBRAHIMPOUR ABOU TALEB. A STUDY ON THE EFFECTIVENESS OF ATORVASTATIN IN THE TREATMENT OF ERECTILE DYSFUNCTION IN HYPERCHOLESTEROLEMIC MEN. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2008;7(1 (56)):106-112. Available from: https://sid.ir/paper/12526/en

IEEE: Copy

M.R. DADFAR, KARIM TAEI, and ABOU TALEB EBRAHIMPOUR, “A STUDY ON THE EFFECTIVENESS OF ATORVASTATIN IN THE TREATMENT OF ERECTILE DYSFUNCTION IN HYPERCHOLESTEROLEMIC MEN,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 7, no. 1 (56), pp. 106–112, 2008, [Online]. Available: https://sid.ir/paper/12526/en

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