A STUDY ON THE EFFECT OF DUAL BLOCKADE OF RENNIN AND ANGIOTENSIN SYSTEMS IN CONTROL OF DIABETIC NEPHROPATHY IN PATIENTS WITH TYPE 2 DIABETIC PATIENTS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHAHBAZIAN H.A.; SHAHBAZIAN H.B.; FEGHHI M.; EHSANPOUR A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Jundishapur Scientific Medical Journal Year:2008 | Volume:7 | Issue:1 (56) Page(s): 85-91

Download Full-Text

Persian Verion

View:

2,851

Download:

Cites:

Information Journal Paper

Title

A STUDY ON THE EFFECT OF DUAL BLOCKADE OF RENNIN AND ANGIOTENSIN SYSTEMS IN CONTROL OF DIABETIC NEPHROPATHY IN PATIENTS WITH TYPE 2 DIABETIC PATIENTS

Author(s)

SHAHBAZIAN H.A. | SHAHBAZIAN H.B. | FEGHHI M. | EHSANPOUR A. | Issue Writer Certificate

Keywords

DIABETIC NEPHROPATHYQ2

LOSARTANQ3

ENALAPRILQ2

Abstract

Objective: Proteinuria and hypertension are predictors of poor renal and cardiovascular outcome in diabetic patients. Blockade of the renin-angiotensin system is an established strategy to interfere with progression of renal failure in diabetic patients. Angiotensinconverting enzyme inhibitors (ACEls) and Angiotensin receptor blockers (ARBs) prevent the progression of DIABETIC NEPHROPATHY (DN). Combination of renin-angiotensin system (RAS)- inhibiting therapy provides additive benefit in type 1 diabetic patients with DIABETIC NEPHROPATHY. This study tested whether this dual blockade is superior to either drug alone in type 2 diabetic patients with DIABETIC NEPHROPATHY (DN).Subjects and Methods: To assess and compare the effects of ENALAPRIL (up to 40 mg/day), LOSARTAN (up to 100 mg/day) and combination therapy (enalapril up to 40mg/day plus LOSARTAN up to 100mg/day) on urinary protein excretion and renal failure progression. 144 type II diabetic patients with DIABETIC NEPHROPATHY (proteinuria>300mg/24h) and normal or slightly reduced renal function (Cr clearance = 76±42mL/min) were enrolled in a twelve months, prospective, open, randomized trial. All patients were re-evalated after 2, 6 and 12 months. Results: One hundred and forty four type 2 diabetic patients with DN (88 male and 66 female; mean age: 53±16.32 years) were recruited. Renal function, estimated by creatinine clearance, remained stable throughout the study. Hyperkalemia was more frequent in patients treated with ENALAPRIL alone or ENALAPRIL plus LOSARTAN (P<0.002) than in those on LOSARTAN alone. The blood pressure goal (<125/75 mm Hg) was achieved by week 8 in all treatment groups (P<0.005 when compared to baseline). Proteinuria decreased significantly in all patients after two months (P<0.001) and remained stable afterward. At the end of study proteinuria was reduced significantly (P<0.05). Combination therapy was statistically more effective in proteinuria reduction than treatment with LOSARTAN alone (P=0.021) and than treatment with ENALAPRIL alone (P=0.018). Conclusion: Dual blockade of the RAS with both an ACEI and ARB is associated with more reduction in proteinuria to either drug alone in type 2 diabetic patients with DN. Antiproteinuric effect during the combined therapy was not related to changes in renal function and blood pressure.

Cites

No record.

References

No record.

Cite

APA: Copy

SHAHBAZIAN, H.A., SHAHBAZIAN, H.B., FEGHHI, M., & EHSANPOUR, A.. (2008). A STUDY ON THE EFFECT OF DUAL BLOCKADE OF RENNIN AND ANGIOTENSIN SYSTEMS IN CONTROL OF DIABETIC NEPHROPATHY IN PATIENTS WITH TYPE 2 DIABETIC PATIENTS. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 7(1 (56)), 85-91. SID. https://sid.ir/paper/12540/en

Vancouver: Copy

SHAHBAZIAN H.A., SHAHBAZIAN H.B., FEGHHI M., EHSANPOUR A.. A STUDY ON THE EFFECT OF DUAL BLOCKADE OF RENNIN AND ANGIOTENSIN SYSTEMS IN CONTROL OF DIABETIC NEPHROPATHY IN PATIENTS WITH TYPE 2 DIABETIC PATIENTS. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2008;7(1 (56)):85-91. Available from: https://sid.ir/paper/12540/en

IEEE: Copy

H.A. SHAHBAZIAN, H.B. SHAHBAZIAN, M. FEGHHI, and A. EHSANPOUR, “A STUDY ON THE EFFECT OF DUAL BLOCKADE OF RENNIN AND ANGIOTENSIN SYSTEMS IN CONTROL OF DIABETIC NEPHROPATHY IN PATIENTS WITH TYPE 2 DIABETIC PATIENTS,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 7, no. 1 (56), pp. 85–91, 2008, [Online]. Available: https://sid.ir/paper/12540/en

Related Journal Papers