COMPARISON OF EFFICACY OF INTRANASAL WITH ORAL ANTI- STAPHYLOCOCCAL TREATMENTS IN CONTROL OF INFECTION AMONG HOSPITAL MRSA CARRIERS

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ALAVI S.M.; RAJABZADEH A.R.; NAGHIBZADEH M.; DEZFOULIAN A.; HAGHIGHIZADEH M.H.

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Journal: Jundishapur Scientific Medical Journal Year:2006 | Volume:4 | Issue:4 (47) Page(s): 288-293

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Title

COMPARISON OF EFFICACY OF INTRANASAL WITH ORAL ANTI- STAPHYLOCOCCAL TREATMENTS IN CONTROL OF INFECTION AMONG HOSPITAL MRSA CARRIERS

Author(s)

Keywords

HOSPITAL CARRIERSQ4

MRSAQ2

HAIQ2

ANTI-STAPHYLOCOCCAL TREATMENTQ4

MUPIROCINQ4

VANCOMYCINQ3

CLOXACILLINQ4

CO -TRIMOXAZOLQ4

RIFAMPICINQ4

Abstract

Objectives: Hospital nasal carriage, among health care staff, of methicillin resistant S. aureus (HNC-MRAS) have an important role in !1°spital-acquired infections (HAI) in admitted patients, which can lead to various complications such as wound infection, catheter related bacterimia, neonatal sepsis, with high mortality rates and socio-economic and health impacts. The aim of the present case-control clinical trial was to compare the efficacy of various antimicrobial treatments in the control of MRSA.Methods: Seventy six HC-MRSA of the heath care staff who were positively identified as HC-MRSA in Razi hospital, an educational hospital of AJUMS, were randomly allocated into 5 groups. The first group was used as placebo-treated control. The remaining groups were treated for seven days twice daily with intra-nasal application of 2% MUPIROCIN ointment, 2% VANCOMYCIN jell, or orally 500 mg CLOXACILLIN QID plus daily 600 mg RIFAMPICIN or 2Tablet adult co-trimoxazol twice daily plus daily 600 mg RIFAMPICIN.Results: The results showed that there was significant reduction in the MRSA following intranasal MUPIROCIN ointment and voncomycin jell which eliminated 93% and 86% of nasal carriage respectively. Oral treatment (cloxacillin 500mg Q6h plus RIFAMPICIN 600 mg daily) or (co-trimoxazol 2 adult tablets Q12h plus 600 mg RIFAMPICIN daily) resulted in 100% elimination of nasal carriers in HNC- MRSA.Conclusion: These results suggest that HNC-MRSA can be controlled with intranasal MUPIROCIN or VANCOMYCIN. In cases that do not respond to topical treatment or due to drug hypersensitivity, CLOXACILLIN plus RIFAMPICIN or co-trimoxazol plus RIFAMPICIN are recommended.

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APA: Copy

ALAVI, S.M., RAJABZADEH, A.R., NAGHIBZADEH, M., DEZFOULIAN, A., & HAGHIGHIZADEH, M.H.. (2006). COMPARISON OF EFFICACY OF INTRANASAL WITH ORAL ANTI- STAPHYLOCOCCAL TREATMENTS IN CONTROL OF INFECTION AMONG HOSPITAL MRSA CARRIERS. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 4(4 (47)), 288-293. SID. https://sid.ir/paper/12750/en

Vancouver: Copy

ALAVI S.M., RAJABZADEH A.R., NAGHIBZADEH M., DEZFOULIAN A., HAGHIGHIZADEH M.H.. COMPARISON OF EFFICACY OF INTRANASAL WITH ORAL ANTI- STAPHYLOCOCCAL TREATMENTS IN CONTROL OF INFECTION AMONG HOSPITAL MRSA CARRIERS. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2006;4(4 (47)):288-293. Available from: https://sid.ir/paper/12750/en

IEEE: Copy

S.M. ALAVI, A.R. RAJABZADEH, M. NAGHIBZADEH, A. DEZFOULIAN, and M.H. HAGHIGHIZADEH, “COMPARISON OF EFFICACY OF INTRANASAL WITH ORAL ANTI- STAPHYLOCOCCAL TREATMENTS IN CONTROL OF INFECTION AMONG HOSPITAL MRSA CARRIERS,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 4, no. 4 (47), pp. 288–293, 2006, [Online]. Available: https://sid.ir/paper/12750/en

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