INTERA-ARTICULAR RIFAMPIN INJECTION IN HEMOPHILIC ARTHEROPATHIES

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ZANDIAN KH.M.; NADERI A.; MOGHTADAEI MANESH H.R.; DEHDASHTI H.; SEYED SARABI M.

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Journal: Jundishapur Scientific Medical Journal Year:2007 | Volume:6 | Issue:2 (53) Page(s): 0-0

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Title

INTERA-ARTICULAR RIFAMPIN INJECTION IN HEMOPHILIC ARTHEROPATHIES

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Keywords

ATHROPATHYQ3

HEMOPHILIAQ3

MRIQ3

RIFAMPINQ3

Abstract

Objective: Hemophilic arthropathy is due to repeated intra-articular bleeding which leads to reduction in the quality of life among HEMOPHILIAcs. There are variety of methods in prevention and treatment of joints complications in these patients, among which intra-articular RIFAMPIN injection is the cheapest with less complications and most beneficial. The aim of this study was to evaluate its effectiveness among our hemophilic patients.Subjects and Methods: The selected patients were among those who were referring to hemophilic clinic of Ahwaz Shafa hospital and were suffering chronic synovitis in target joints. Pre- and post- treatment (3 to 6 months later) as well as clinical examination (as set by World Federation of HEMOPHILIA Guideline) and MRI of involved joints were performed. The intra-articular injection protocols were as following: in the knee RIFAMPIN 500mg + lidocaine weekly for 10 weeks, in the elbow, ankle and shoulder joints 250mg RIFAMPIN + lidocoine for 5 weeks.Results: Intra-articular injections were performed in 9 hemophilic patients with 11 affected hemophilic joints. Clinical signs and MRI showed dramatic improvement in 6 patients. Outcome was not favorable in 3 patients due to advanced disease and joint destruction.Conclusion: Intra-articular RIFAMPIN injection is a suitable method for prevention of bleeding, improvement of clinical signs and quality of life in most un-advanced cases of hemophilic arthropathy. Furthermore, MRI hyperplasia and hypertrophy of synovium, bone cysts, joint cartilage loss, precipitation of hemosiderin and osteonecrosis are better evaluated with MRI than plain radiography or clinical examination, at pre- and post treatment stages.

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APA: Copy

ZANDIAN, KH.M., MOGHTADAEI MANESH, H.R., NADERI, A., DEHDASHTI, H., & SEYED SARABI, M.. (2007). INTERA-ARTICULAR RIFAMPIN INJECTION IN HEMOPHILIC ARTHEROPATHIES. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 6(2 (53)), 0-0. SID. https://sid.ir/paper/12804/en

Vancouver: Copy

ZANDIAN KH.M., MOGHTADAEI MANESH H.R., NADERI A., DEHDASHTI H., SEYED SARABI M.. INTERA-ARTICULAR RIFAMPIN INJECTION IN HEMOPHILIC ARTHEROPATHIES. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2007;6(2 (53)):0-0. Available from: https://sid.ir/paper/12804/en

IEEE: Copy

KH.M. ZANDIAN, H.R. MOGHTADAEI MANESH, A. NADERI, H. DEHDASHTI, and M. SEYED SARABI, “INTERA-ARTICULAR RIFAMPIN INJECTION IN HEMOPHILIC ARTHEROPATHIES,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 6, no. 2 (53), pp. 0–0, 2007, [Online]. Available: https://sid.ir/paper/12804/en

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