THE PREVENTIVE EFFECT OF VITAMIN E ON CADMIUM CHLORIDE-INDUCED TOXICITY IN RAT LIVER AND KIDNEY

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AHMADIZADEH MASOUMEH; BAGH PA A.A.R.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Jundishapur Scientific Medical Journal Year:2008 | Volume:6 | Issue:4 (55) Page(s): 404-413

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,640

Download:

Cites:

Information Journal Paper

Title

THE PREVENTIVE EFFECT OF VITAMIN E ON CADMIUM CHLORIDE-INDUCED TOXICITY IN RAT LIVER AND KIDNEY

Author(s)

AHMADIZADEH MASOUMEH | BAGH PA A.A.R. | Issue Writer Certificate

Keywords

CADMIUM CHORIDEQ3

VITAMIN EQ2

LIVERQ2

KIDNEYQ2

RATQ2

Abstract

Objective: Environmental exposure to cadmium (Cd) occurs via food, occupational industries, terrestrial and aquatic ecosystem. Increasing evidence indicated that Cd induced toxicity in human and animals. However, the mechanism by which it’s produced toxicity is not completely understood. It has been shown that lipid peroxidation is involved in Cd-related toxicity. VITAMIN E is an effective antioxidant and tree radical scavenger. The aim of this study is to investigate the preventive effect of VITAMIN E on cadmium-induced toxicity in RAT LIVER and KIDNEY. .Materials and Methods: Adult NMARI male RATs were treated with 5mglkg VITAMIN E or corn oil (vehicle) only. 30 min later animals were given Cd CL2 (ip) at doses of 0.5, 1, 1.5 and 2mg/kg. The control group received normal saline (vehicle). All animals were treated for 7 consecutive days. 24 hr after last administration all RATs were killed with over dose of sodium pentobarbital. The blood was collected for determinations of ALT, AST, ALP, BUN and creatinine. The LIVER and KIDNEY tissues were removed, fixed and processed for light microscopy, using H&E staining method. CdCl2 induced dose-dependent injury in both LIVER and KIDNEY tissues.Results: Statistical analysis showed significant increase all biochemical parameters in CdCl2 treated RATs when compared to control groups (p>0.05). VITAMIN E had no effect on RAT LIVER or KIDNEY. However, this agent protected cells against CdCl2 toxicity.Conclusion: The results of this study support the view that VITAMIN E has potential to protect RAT LIVER and KIDNEY tissues against CdCl2 toxicity.

Cites

PROTECTIVE EFFECTS OF BLACK IRANIAN TEA ON CADMIUM- INDUCED HEPATOTOXICITY IN RATS

References

No record.

Cite

APA: Copy

AHMADIZADEH, MASOUMEH, & BAGH PA, A.A.R.. (2008). THE PREVENTIVE EFFECT OF VITAMIN E ON CADMIUM CHLORIDE-INDUCED TOXICITY IN RAT LIVER AND KIDNEY. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 6(4 (55)), 404-413. SID. https://sid.ir/paper/12845/en

Vancouver: Copy

AHMADIZADEH MASOUMEH, BAGH PA A.A.R.. THE PREVENTIVE EFFECT OF VITAMIN E ON CADMIUM CHLORIDE-INDUCED TOXICITY IN RAT LIVER AND KIDNEY. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2008;6(4 (55)):404-413. Available from: https://sid.ir/paper/12845/en

IEEE: Copy

MASOUMEH AHMADIZADEH, and A.A.R. BAGH PA, “THE PREVENTIVE EFFECT OF VITAMIN E ON CADMIUM CHLORIDE-INDUCED TOXICITY IN RAT LIVER AND KIDNEY,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 6, no. 4 (55), pp. 404–413, 2008, [Online]. Available: https://sid.ir/paper/12845/en

Related Journal Papers