RICIN TOXIN; MECHANISMS OF TOXICITY, DIAGNOSIS METHODS, TREATMENT AND IMMUNIZATION AGAINST IT

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SADEGHI DAVOUD; EBRAHIMI FIROUZ; ZEINODDINI MEHDI; HOSSEINI SEYED AMIR; HEDAYAT MANESH ZOHREH

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Journal: Jundishapur Scientific Medical Journal Year:2017 | Volume:16 | Issue:1 Page(s): 103-124

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Title

RICIN TOXIN; MECHANISMS OF TOXICITY, DIAGNOSIS METHODS, TREATMENT AND IMMUNIZATION AGAINST IT

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Keywords

RICIN TOXINQ1

DIAGNOSISQ1

TREATMENTQ3

VACCINE DEVELOPMENTQ1

Abstract

RICIN TOXIN is a disulfide-linked heterodimeric glycoprotein consisting of the toxic A chain and the cell-binding B chain that acts through the irreversible inactivation of eukaryotic ribosomes and inhibition of the polypeptide chain elongation, which finally leads to cell death. The toxin is extracted from castor plant beans (Ricinus communis) and it consists of 1–5% of the beans’ dry weight. Ricin is of concern in the area of biodefense because it is readily available to individuals or groups with little technical expertise or funding and its source is ubiquitous in the weed and in the cultivated crop in many countries. Since ricin can easily be distribute in the body, it has been classified by the CDC (US center for Disease Control and Prevention) as a class B biothreat. There has been much investigation on the DIAGNOSIS, TREATMENT and production of a potent vaccine against this agent. For DIAGNOSIS of ricin poisoning in clinical cases, immunological techniques have been used for screening of samples and combination of high tech chromatographic and mass spectrometric methods could be used for poisoning confirmative analysis. There is currently no specific TREATMENT available for poisoning with ricin but two closely related RTA-based subunit vaccines, contain RiVax and RVEc, are now under development. The aim of this study is presentation of RICIN TOXIN, DIAGNOSIS methods, TREATMENT and new vaccine candidates against it.

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APA: Copy

SADEGHI, DAVOUD, EBRAHIMI, FIROUZ, ZEINODDINI, MEHDI, HOSSEINI, SEYED AMIR, & HEDAYAT MANESH, ZOHREH. (2017). RICIN TOXIN; MECHANISMS OF TOXICITY, DIAGNOSIS METHODS, TREATMENT AND IMMUNIZATION AGAINST IT. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 16(1 ), 103-124. SID. https://sid.ir/paper/12961/en

Vancouver: Copy

SADEGHI DAVOUD, EBRAHIMI FIROUZ, ZEINODDINI MEHDI, HOSSEINI SEYED AMIR, HEDAYAT MANESH ZOHREH. RICIN TOXIN; MECHANISMS OF TOXICITY, DIAGNOSIS METHODS, TREATMENT AND IMMUNIZATION AGAINST IT. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2017;16(1 ):103-124. Available from: https://sid.ir/paper/12961/en

IEEE: Copy

DAVOUD SADEGHI, FIROUZ EBRAHIMI, MEHDI ZEINODDINI, SEYED AMIR HOSSEINI, and ZOHREH HEDAYAT MANESH, “RICIN TOXIN; MECHANISMS OF TOXICITY, DIAGNOSIS METHODS, TREATMENT AND IMMUNIZATION AGAINST IT,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 16, no. 1 , pp. 103–124, 2017, [Online]. Available: https://sid.ir/paper/12961/en

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