THE PRETREATMENT EFFECTS OF ENDURANCE TRAINING ON DOXORUBICIN-INDUCED STRESS IN WISTER RATS

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JAMALI SHABNAM; DABIDI ROSHAN VALIOLLAH; AFSHAN SAMANEH

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Journal: Pars Journal of Medical Sciences Year:2016 | Volume:14 | Issue:1 Page(s): 45-54

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Title

THE PRETREATMENT EFFECTS OF ENDURANCE TRAINING ON DOXORUBICIN-INDUCED STRESS IN WISTER RATS

Author(s)

JAMALI SHABNAM | DABIDI ROSHAN VALIOLLAH | AFSHAN SAMANEH | Issue Writer Certificate

Keywords

HEAT SHOCK PROTEIN 72Q1

CATALASEQ2

DOXORUBICINQ2

OXIDATIVE STRESSQ2

Abstract

Introduction: This study aimed to investigate the preventive effects of resistance training on heat shock protein and the hepatic level of CATALASE in Wister rats following acute administration of DOXORUBICIN.Materials and Methods: The statistical population consisted of 72 male rats (60 days) randomly divided into control and exercise groups. The exercise group was then divided into two groups of 3 and 6 weeks training. At the end of the exercise period, the exercise groups were randomly divided into subgroups to receive specific doses of DOXORUBICIN 24 hours after the last training session (10 mg/kg bw and 20 mg/kg bw) and saline 0.9 percent. After the biopsy, ELISA method was used to measure levels of HSP72 and CATALASE in the liver.Results: A significant increase was observed in HSP72 levels in the control/DXR20 groups compared to control/saline groups (p=0.001). Injecting a dose of 20 mg/kg bw after 3 and 6 weeks training caused a significant increase in CATALASE, compared to the 3 and 6 weeks exercise/saline groups (p=0.001, 0.003).Conclusion: The use of non-pharmacological methods such as medium-term and short-term resistance exercise before administering DOXORUBICIN can reduce drug-induced liver toxicity through supportive mechanisms and decreasing the OXIDATIVE STRESS and can be used as a protective approach before administering DOXORUBICIN.

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APA: Copy

JAMALI, SHABNAM, DABIDI ROSHAN, VALIOLLAH, & AFSHAN, SAMANEH. (2016). THE PRETREATMENT EFFECTS OF ENDURANCE TRAINING ON DOXORUBICIN-INDUCED STRESS IN WISTER RATS. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), 14(1), 45-54. SID. https://sid.ir/paper/131007/en

Vancouver: Copy

JAMALI SHABNAM, DABIDI ROSHAN VALIOLLAH, AFSHAN SAMANEH. THE PRETREATMENT EFFECTS OF ENDURANCE TRAINING ON DOXORUBICIN-INDUCED STRESS IN WISTER RATS. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL)[Internet]. 2016;14(1):45-54. Available from: https://sid.ir/paper/131007/en

IEEE: Copy

SHABNAM JAMALI, VALIOLLAH DABIDI ROSHAN, and SAMANEH AFSHAN, “THE PRETREATMENT EFFECTS OF ENDURANCE TRAINING ON DOXORUBICIN-INDUCED STRESS IN WISTER RATS,” PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), vol. 14, no. 1, pp. 45–54, 2016, [Online]. Available: https://sid.ir/paper/131007/en

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