THE EFFECTS OF MODERATE-INTENSITY INTERVAL TRAINING ON THE RESISTANCE TO INDUCED CARDIAC ISCHEMIA IN ADULT MALE RATS

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MAREFATI HAMID; AMINIZADEH SOHEIL; NAJAFIPOUR HAMID; DABIRI SHAHRIAR; Shahouzehi Beydollah

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Journal: QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL Year:2016 | Volume:10 | Issue:4 Page(s): 1-9

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Title

THE EFFECTS OF MODERATE-INTENSITY INTERVAL TRAINING ON THE RESISTANCE TO INDUCED CARDIAC ISCHEMIA IN ADULT MALE RATS

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Keywords

CARDIAC FUNCTION TESTQ1

ISOPROTERENOLQ1

MYOCARDIAL REPERFUSION INJURYQ1

EXERCISEQ2

Abstract

Background and Objectives: Myocardial infarction is one the major causes of mortality in the world. The purpose of this study was to investigate the effects of moderate-intensity interval training on the level of resistance to induced cardiac ischemia in male adult rats.Methods: In this study, 16 adult male Wistar rats were randomly divided into two groups of 8 mice: Control and moderate-intensity interval training (MIIT). At the end of 16th week of the training, all rats intraperitoneally received ISOPROTERENOL (dose, 85mg/kg) for 2 consecutive days, then cardiac function parameters [heart rate, diastolic blood pressure (DBP), systolic blood pressure (SBP), left ventricular±dp/dt max], Biochemical indicators of tissue damage (heart tissue CTnI and TNF-a) were measured; also, the extent of heart tissue damage was evaluated by histopathological examination. The data were analyzed using nonparametric Mann-Whitney test and independent t-test. The significance level was considered as p≤0.05.Results: No significant differences were seen between the groups in any of the cardiac function parameters [HR (p<0.130), SBP (p<0.48) and DBP (p<0.72)]. However, other cardiac function parameters including left ventricular±dp/dt max in the EXERCISE group was significantly different from the control group (p<0.01). The heart tissue CTnI in the EXERCISE group was significantly higher than the control group (p<0.009). The heart tissue TNF-a in the EXERCISE group was significantly lower than the control group (p<0.029). Histopathological examinations showed the positive effect of EXERCISE protocol on the reduction of tissue damage in ischemic (p<0.003).Conclusion: The results showed that moderate-intensity interval training has protective effects against cardiac damage caused by injection of ISOPROTERENOL.

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APA: Copy

MAREFATI, HAMID, AMINIZADEH, SOHEIL, NAJAFIPOUR, HAMID, DABIRI, SHAHRIAR, & Shahouzehi, Beydollah. (2016). THE EFFECTS OF MODERATE-INTENSITY INTERVAL TRAINING ON THE RESISTANCE TO INDUCED CARDIAC ISCHEMIA IN ADULT MALE RATS. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 10(4), 1-9. SID. https://sid.ir/paper/131850/en

Vancouver: Copy

MAREFATI HAMID, AMINIZADEH SOHEIL, NAJAFIPOUR HAMID, DABIRI SHAHRIAR, Shahouzehi Beydollah. THE EFFECTS OF MODERATE-INTENSITY INTERVAL TRAINING ON THE RESISTANCE TO INDUCED CARDIAC ISCHEMIA IN ADULT MALE RATS. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2016;10(4):1-9. Available from: https://sid.ir/paper/131850/en

IEEE: Copy

HAMID MAREFATI, SOHEIL AMINIZADEH, HAMID NAJAFIPOUR, SHAHRIAR DABIRI, and Beydollah Shahouzehi, “THE EFFECTS OF MODERATE-INTENSITY INTERVAL TRAINING ON THE RESISTANCE TO INDUCED CARDIAC ISCHEMIA IN ADULT MALE RATS,” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 10, no. 4, pp. 1–9, 2016, [Online]. Available: https://sid.ir/paper/131850/en

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