ANTI-CANCER EFFECT OF NANO ZINC OXIDE ON MALIGNANT HN5 CELL LINE IN IN VITRO CULTURE

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HOVEIZI ELHAM; MOHAMMADI TAYEBEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Qom University of Medical Sciences Journal Year:2017 | Volume:11 | Issue:10 Page(s): 21-29

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Title

ANTI-CANCER EFFECT OF NANO ZINC OXIDE ON MALIGNANT HN5 CELL LINE IN IN VITRO CULTURE

Author(s)

HOVEIZI ELHAM | MOHAMMADI TAYEBEH | Issue Writer Certificate

Keywords

NEOPLASMSQ2

ZINC OXIDEQ1

CELL SURVIVALQ1

HEAD AND NECK NEOPLASMSQ1

Abstract

Background and Objectives: Head and neck cell carcinoma cell lines (HN-5) are considered as an appropriate preclinical model for new therapeutic purposes for this type of cancer. Unlike other cancers, Various primary and metastatic HN5 cell lines are available. The aim of this study was to investigate the anti-cancer effect of nano ZINC OXIDE (ZnO) on viability of malignant HN5 cell line.Methods: In this experimental study, HN5 cell line was cultured in DMEM medium (containing 10% FBS and penicillin/streptomycin) at 37oC. Then, the effect of different concentrations of ZnO on these cells, were assessed by MTT and DAPI staining. The results were evaluated with completely randomized block design ANOVA.Results: In this study, some concentrations of ZnO were effective in cytotoxicity of HN5 cancer cells. Also, 300mg/ml was the concentration of the studied compound that reduced the highest percentage of cell viability.Conclusion: The results of this study showed that ZnO has ability to induce cytotoxicity in HN5 cancer cell line in higher concentrations (about 300mg/ml), that these findings These findings provide a new perspective on the use nanoparticles in the cancer chemotherapy.

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APA: Copy

HOVEIZI, ELHAM, & MOHAMMADI, TAYEBEH. (2017). ANTI-CANCER EFFECT OF NANO ZINC OXIDE ON MALIGNANT HN5 CELL LINE IN IN VITRO CULTURE. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 11(10 ), 21-29. SID. https://sid.ir/paper/131932/en

Vancouver: Copy

HOVEIZI ELHAM, MOHAMMADI TAYEBEH. ANTI-CANCER EFFECT OF NANO ZINC OXIDE ON MALIGNANT HN5 CELL LINE IN IN VITRO CULTURE. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2017;11(10 ):21-29. Available from: https://sid.ir/paper/131932/en

IEEE: Copy

ELHAM HOVEIZI, and TAYEBEH MOHAMMADI, “ANTI-CANCER EFFECT OF NANO ZINC OXIDE ON MALIGNANT HN5 CELL LINE IN IN VITRO CULTURE,” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 11, no. 10 , pp. 21–29, 2017, [Online]. Available: https://sid.ir/paper/131932/en

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