Drug Resistance Pattern of Toxigenic Clostridium difficileIsolated from Patients with Diarrhea to Conventional Therapeutic Drugs with Chronic

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Zargar Mohsen; GHADIR MOHAMMAD REZA; JAVADI ALI; MOROVVATI ABBAS; DASTJANI FARAHANI FARIBA

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL Year:2020 | Volume:13 | Issue:11 Page(s): 13-23

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

569

Download:

Cites:

Information Journal Paper

Title

Drug Resistance Pattern of Toxigenic Clostridium difficileIsolated from Patients with Diarrhea to Conventional Therapeutic Drugs with Chronic

Author(s)

Keywords

Clostridium difficileQ1

DiarrheaQ1

Toxin AQ1

Toxin BQ1

Polymerase chain reactionQ2

Drug resistanceQ2

Abstract

Background and Objectives: Clostridium difficile is a gram-positive obligate anaerobic bacillus. Accurate and rapid diagnosis of this bacterium as well as assessment of its Drug resistance pattern are one of the important issues in controlling infections caused by C. difficile. The purpose of the present study was to detect toxicogenic C. difficile and to evaluate Drug resistance pattern of these strains to routine therapeutic drugs. Methods: A total of 68 samples were collected from patients hospitalized in hospitals of Qom province. All samples were rapidly cultured in the specialized CCFA Agar medium. After these procedures, the bacteria were used for DNA extraction and then PCR was performed on the cdd3 gene for definitive detection of the bacteria. Finally, the presence of A and B toxins’ genes was determined by PCR and resistance to metronidazole, vancomycin, and clindamycin, was determined by agar dilution method. Chi-square test was used to analyze the results. Results: In this study, 6 isolates had A and B toxins, the highest antibiotic resistance was against clindamycin (45. 45%) and metronidazole (36. 36%), and all the isolates, were sensitive to vancomycin. Conclusion: Drug resistance pattern in the obtained strains still introduces vancomycin as the treatment of choice.

Cites

No record.

References

Cite

APA: Copy

Zargar, Mohsen, GHADIR, MOHAMMAD REZA, JAVADI, ALI, MOROVVATI, ABBAS, & DASTJANI FARAHANI, FARIBA. (2020). Drug Resistance Pattern of Toxigenic Clostridium difficileIsolated from Patients with Diarrhea to Conventional Therapeutic Drugs with Chronic. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 13(11 ), 13-23. SID. https://sid.ir/paper/132212/en

Vancouver: Copy

Zargar Mohsen, GHADIR MOHAMMAD REZA, JAVADI ALI, MOROVVATI ABBAS, DASTJANI FARAHANI FARIBA. Drug Resistance Pattern of Toxigenic Clostridium difficileIsolated from Patients with Diarrhea to Conventional Therapeutic Drugs with Chronic. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2020;13(11 ):13-23. Available from: https://sid.ir/paper/132212/en

IEEE: Copy

Mohsen Zargar, MOHAMMAD REZA GHADIR, ALI JAVADI, ABBAS MOROVVATI, and FARIBA DASTJANI FARAHANI, “Drug Resistance Pattern of Toxigenic Clostridium difficileIsolated from Patients with Diarrhea to Conventional Therapeutic Drugs with Chronic,” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 13, no. 11 , pp. 13–23, 2020, [Online]. Available: https://sid.ir/paper/132212/en

Related Journal Papers