Use of Low Molecular Weight Antigens of Mycobacterium tuberculosis as a New Skin Test for Specific Diagnosis of Tuberculosis

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SADEGHI GARIZ DAVOUD; MOSAVARI NADER

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Journal: QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL Year:2018 | Volume:12 | Issue:1 Page(s): 63-71

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Title

Use of Low Molecular Weight Antigens of Mycobacterium tuberculosis as a New Skin Test for Specific Diagnosis of Tuberculosis

Author(s)

SADEGHI GARIZ DAVOUD | MOSAVARI NADER | Issue Writer Certificate

Keywords

Skin testsQ1

TuberculosisQ2

Tuberculosis-diagnosisQ1

Abstract

Background and Objectives: Tuberculosis (TB) is an infectious disease and about one-third of the world population are infected with latent TB infection. Active TB infection may develop in 5 to10 percent of individuals with latent infection; therefore, detection of latent infection is of great importance in the control of the disease. The aim of this study was to develop a specific skin test based on low molecular weight proteins secreted by M. Tuberculosis for detection of M. Tuberculosis infection. Methods: At this study, after extraction of secreted proteins from shortterm culture filtrate of M. Tuberculosis, low molecular weight proteins, were purified by Sephadex-G75 gel chromatography. For skin test, several groups of guinea pigs were sensitized with M. Tuberculosis, M. bovis BCG, and M. avium strains, and then skin test were performed using purified proteins and PPD. Results: According to skin test data, unlike PPD, purified proteins showed a positive response in animals exposed to M. Tuberculosis, but no significant skin responses was observed in the guinea pigs sensitized with M. bovis BCG and M. avium strains. Conclusion: The results of this study demonstrated that new skin test is specific compared to PPD in the detection of M. Tuberculosis infection, and could be replaced as a more specific skin test for detection of TB in large animals or human.

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APA: Copy

SADEGHI GARIZ, DAVOUD, & MOSAVARI, NADER. (2018). Use of Low Molecular Weight Antigens of Mycobacterium tuberculosis as a New Skin Test for Specific Diagnosis of Tuberculosis. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 12(1 ), 63-71. SID. https://sid.ir/paper/132390/en

Vancouver: Copy

SADEGHI GARIZ DAVOUD, MOSAVARI NADER. Use of Low Molecular Weight Antigens of Mycobacterium tuberculosis as a New Skin Test for Specific Diagnosis of Tuberculosis. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2018;12(1 ):63-71. Available from: https://sid.ir/paper/132390/en

IEEE: Copy

DAVOUD SADEGHI GARIZ, and NADER MOSAVARI, “Use of Low Molecular Weight Antigens of Mycobacterium tuberculosis as a New Skin Test for Specific Diagnosis of Tuberculosis,” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 12, no. 1 , pp. 63–71, 2018, [Online]. Available: https://sid.ir/paper/132390/en

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