THE HISTOLOGICAL EFFECTS OF L-ARGININE ON VENTRICULAR MYOCARDIUM IN IRON TREATED MALE RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SOUFIABADI M.; RAJAEI F.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Qom University of Medical Sciences Journal Year:2010 | Volume:4 | Issue:1 Page(s): 10-14

Download Full-Text

Persian Verion

View:

807

Download:

Cites:

Information Journal Paper

Title

THE HISTOLOGICAL EFFECTS OF L-ARGININE ON VENTRICULAR MYOCARDIUM IN IRON TREATED MALE RATS

Author(s)

SOUFIABADI M. | RAJAEI F. | Issue Writer Certificate

Keywords

IRONQ2

L-ARGININEQ2

HISTOLOGICAL EFFECTQ3

MYOCARDIUMQ3

Abstract

Background and Objectives: IRON overload is detrimental for the body and can create damage to different body tissues such as MYOCARDIUM by producing oxidative stress. Therefore the antioxidant factors can neutralize IRON induced damages. According to available reports L-ARGININE as a precursor nitric oxide production has antioxidant effects. This study was carried out to evaluate the HISTOLOGICAL EFFECTs of IRON overload on ventricular muscle and preventive role of L-ARGININE in male rats. Methods: In this experiment 40 male rats with weight range of 300-250g were divided at random into five equal groups including:1- Control 2- IRON (10mg/kg ip) 3- IRON(10mg/kg ip)+L-arginine (1mg/ml po) 4- IRON (50mg/kg ip) and 5- IRON (50mg/kgip)+L-arginine(1mg/mlpo). After treatment (6 weeks) the animals were anesthetized and the samples of left apical ventricular MYOCARDIUM were taken out and morphological studies were done following fixation with 10% formalin and H&E staining. Microscopic parameters under study were cell swelling vessel dilatation and hypercongestion cell necrosis and tissue deformity. The type and severity of damage to the tissue were also noted. Data were analyzed using chi-square statistical procedure and Pvalue≤0.05 were considered to be significant. Results: The data showed moderate changes in the ventricular MYOCARDIUM of group 2 that was significant in comparison to the control group (P<0.01). The low change showed in the ventricular MYOCARDIUM of group 5 that wasn’t significant in comparison to the control group.Conclusion: This study showed that excess IRON can cause unfavorable changes in myocardial tissue and L-ARGININE may reduce IRON overload damage. Therefore, L-ARGININE can protect myocardial tissue against IRON overload stress.

Cites

No record.

References

No record.

Cite

APA: Copy

SOUFIABADI, M., & RAJAEI, F.. (2010). THE HISTOLOGICAL EFFECTS OF L-ARGININE ON VENTRICULAR MYOCARDIUM IN IRON TREATED MALE RATS. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 4(1), 10-14. SID. https://sid.ir/paper/132454/en

Vancouver: Copy

SOUFIABADI M., RAJAEI F.. THE HISTOLOGICAL EFFECTS OF L-ARGININE ON VENTRICULAR MYOCARDIUM IN IRON TREATED MALE RATS. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2010;4(1):10-14. Available from: https://sid.ir/paper/132454/en

IEEE: Copy

M. SOUFIABADI, and F. RAJAEI, “THE HISTOLOGICAL EFFECTS OF L-ARGININE ON VENTRICULAR MYOCARDIUM IN IRON TREATED MALE RATS,” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 4, no. 1, pp. 10–14, 2010, [Online]. Available: https://sid.ir/paper/132454/en

Related Journal Papers