EFFECT OF AQUEOUS SEED EXTRACT OF SECURIGERA SECURIDACA ON ERYTHROCYTES CATALASE ACTIVITY IN TYPE 1 DIABETIC RATS

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ROUSTAZADEH ABAZAR; FIROUZRAI M.; SHAABANI MOHAMMAD

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Journal: QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL Year:2008 | Volume:1 | Issue:4 Page(s): 9-13

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Title

EFFECT OF AQUEOUS SEED EXTRACT OF SECURIGERA SECURIDACA ON ERYTHROCYTES CATALASE ACTIVITY IN TYPE 1 DIABETIC RATS

Author(s)

ROUSTAZADEH ABAZAR | FIROUZRAI M. | SHAABANI MOHAMMAD | Issue Writer Certificate

Keywords

CATALASEQ2

DIABETES MELLITUSQ3

TYPE1Q2

OXIDATIVE STRESSQ3

ANTIOXIDANT SECURIGERA SECURIDACAQ2

Abstract

Background and objective: Complications in DIABETES MELLITUS are associated with free radicals and OXIDATIVE STRESS. The human body prevents these complications through antioxidant defense mechanisms. The aim of the study was to investigate the effect of aqueous seed extract of Securigera Securidaca on erythrocyte CATALASE activity in TYPE1 diabetic rats. Methods: At the present interventional study thirty male wistar rats were used. Animals were divided to two groups including normal and diabetic (n=15 per each group).Each group was divided further to control and experimental subgroups. The experimental subgroups were received 100 and 200 mg/kg/day of the plant extract intraperitoneally. After thirty days administration, blood sample was directly collected from the heart and erythrocyte CATALASE activity was assessed.Results: CATALASE activity decreased in diabetic control group significantly (P=0.002).Furthermore, CATALASE activity in groups treated at two doses of 100mg/kg and 200mg/kg was significantly different as compared to control group (P=0.003). Conclusion: The aqueous seed extract of Securigera Securidaca probably could be effective in decreasing diabetic complications through improvement of antioxidant response by altering CATALASE activity and consequently reducing OXIDATIVE STRESS.

Cites

THE EFFECT OF POMEGRANATE JUICE ON SOME FACTORS OF HEMOGRAM AND WEIGHT IN DIABETIC MATURE MALE RATS

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APA: Copy

ROUSTAZADEH, ABAZAR, FIROUZRAI, M., & SHAABANI, MOHAMMAD. (2008). EFFECT OF AQUEOUS SEED EXTRACT OF SECURIGERA SECURIDACA ON ERYTHROCYTES CATALASE ACTIVITY IN TYPE 1 DIABETIC RATS. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 1(4), 9-13. SID. https://sid.ir/paper/132486/en

Vancouver: Copy

ROUSTAZADEH ABAZAR, FIROUZRAI M., SHAABANI MOHAMMAD. EFFECT OF AQUEOUS SEED EXTRACT OF SECURIGERA SECURIDACA ON ERYTHROCYTES CATALASE ACTIVITY IN TYPE 1 DIABETIC RATS. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2008;1(4):9-13. Available from: https://sid.ir/paper/132486/en

IEEE: Copy

ABAZAR ROUSTAZADEH, M. FIROUZRAI, and MOHAMMAD SHAABANI, “EFFECT OF AQUEOUS SEED EXTRACT OF SECURIGERA SECURIDACA ON ERYTHROCYTES CATALASE ACTIVITY IN TYPE 1 DIABETIC RATS,” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 1, no. 4, pp. 9–13, 2008, [Online]. Available: https://sid.ir/paper/132486/en

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