THE EFFECT OF DECREASED ACTIVITY IN THE FORM OF NEUROPATHIC PAIN ON GSK-3β GENE EXPRESSION IN SCIATIC NERVE FIBER OF MALE WISTAR RATS

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RAHMATI MASOUD; Ghanbarzadeh Mokhtar; AGHAE MOHAMMAD HASSAN

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Journal: QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL Year:2018 | Volume:12 | Issue:2 Page(s): 11-18

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Title

THE EFFECT OF DECREASED ACTIVITY IN THE FORM OF NEUROPATHIC PAIN ON GSK-3β GENE EXPRESSION IN SCIATIC NERVE FIBER OF MALE WISTAR RATS

Author(s)

RAHMATI MASOUD | Ghanbarzadeh Mokhtar | AGHAE MOHAMMAD HASSAN | Issue Writer Certificate

Keywords

NEURALGIAQ1

HYPOKINESIAQ1

GLYCOGEN SYNTHASE KINASE-3 BETAQ1

Abstract

Background and Objectives: Studies have shown that impairment in kinases in the nervous system is related to many neurodegenerative disease. Glycogen synthase kinase-3b (GSK-3b) is a serine/threonine kinase that participates in regulation of various functions of neurons. Accordingly, GSK-3b is one of the drug targets for nervous system therapies. In this study, the effect of decreased activity in the form of neuropathic pain, was investigated on GSK-3b gene expression in sciatic nerve fiber of male Wistar rats.Methods: In this experimental study, 12 male Wistar rats (mean weight, 250±30g), were randomly divided into two groups: 1) Decreased activity (SNL: n=5); 2) Control (C: n=5). During and at the end of the protocol, neuropathic pain behavior tests, were performed continuously in the groups. After sixth weeks, the level of GSK-3b gene expression in sciatic nerve, was measured by real time technique and calculated using the 2-DDCT method. Data were analyzed using two-way repeated measures analysis of variance and independent t-test.Results: After 6 weeks, neuropathic pain behavior tests of mechanical allodynia and thermal hyperalgesia showed that pain threshold was significantly lower in the SNL group than the control group (p£0.05). In addition, GSK-3b gene expression significantly increased in the sciatic nerve ligation group compared to the control group (p£0.05).Conclusion: The results of this study showed that mechanical allodynia, thermal hyperalgesia, and decreased physical activity are related to increased GSK-3b gene expression in sciatic nerve fiber.

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APA: Copy

RAHMATI, MASOUD, Ghanbarzadeh, Mokhtar, & AGHAE, MOHAMMAD HASSAN. (2018). THE EFFECT OF DECREASED ACTIVITY IN THE FORM OF NEUROPATHIC PAIN ON GSK-3β GENE EXPRESSION IN SCIATIC NERVE FIBER OF MALE WISTAR RATS. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 12(2 ), 11-18. SID. https://sid.ir/paper/132491/en

Vancouver: Copy

RAHMATI MASOUD, Ghanbarzadeh Mokhtar, AGHAE MOHAMMAD HASSAN. THE EFFECT OF DECREASED ACTIVITY IN THE FORM OF NEUROPATHIC PAIN ON GSK-3β GENE EXPRESSION IN SCIATIC NERVE FIBER OF MALE WISTAR RATS. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2018;12(2 ):11-18. Available from: https://sid.ir/paper/132491/en

IEEE: Copy

MASOUD RAHMATI, Mokhtar Ghanbarzadeh, and MOHAMMAD HASSAN AGHAE, “THE EFFECT OF DECREASED ACTIVITY IN THE FORM OF NEUROPATHIC PAIN ON GSK-3β GENE EXPRESSION IN SCIATIC NERVE FIBER OF MALE WISTAR RATS,” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 12, no. 2 , pp. 11–18, 2018, [Online]. Available: https://sid.ir/paper/132491/en

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