A COMPARATIVE SURVEY OF THE EFFECTS OF FLUOXETINE AND IMIPRAMINE ON DEPRESSION-LIKE BEHAVIOR AND SERUM LEVELS OF CORTICOSTERONE AND GLUCOSE IN MALE RATS UNDER IMMOBILIZATION STRESS

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BAYRAMLOU RAZIEH; MOHAMMADZADEH MEHDI; BABAEI BALDERLOU FARIN

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Journal: QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL Year:2018 | Volume:12 | Issue:2 Page(s): 1-10

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Title

A COMPARATIVE SURVEY OF THE EFFECTS OF FLUOXETINE AND IMIPRAMINE ON DEPRESSION-LIKE BEHAVIOR AND SERUM LEVELS OF CORTICOSTERONE AND GLUCOSE IN MALE RATS UNDER IMMOBILIZATION STRESS

Author(s)

BAYRAMLOU RAZIEH | MOHAMMADZADEH MEHDI | BABAEI BALDERLOU FARIN | Issue Writer Certificate

Keywords

RESTRAINTQ1

PHYSICALQ1

FLUOXETINEQ1

IMIPRAMINEQ1

TAIL SUSPENSION TESTQ3

CORTICOSTERONEQ3

GLUCOSEQ3

Abstract

Background and Objectives: Depression is one of the most common psychiatric disorders, which can be detected and continued through stressful life events. Since the medical treatment of depression, is long-term use of antidepressants, therefore, this research was performed to compare the effects of FLUOXETINE and IMIPRAMINE on depression.Methods: In this experimental study, 24 male Wistar rats (age range, 180±20gr), were used. Animals were divided into four groups of 6 each, including: Control, under immobilization stress, FLUOXETINE-treated (dose, 20mg/kg), and the IMIPRAMINE-treated (dose, 30mg/kg). Induction of immobilization stress was conducted by limiting polyethylene for 14 days. At the end of the treatment period, the antidepressant effects of the drugs in the treatment groups, were evaluated using TAIL SUSPENSION TEST. Then, serum levels of CORTICOSTERONE and GLUCOSE, were measured.Results: In this study, the immobility time in the patient group significantly increased as compared to the control group. However, administration of FLUOXETINE and IMIPRAMINE decreased immobility time compared to the patient group. Also, immobilization stress significantly decreased CORTICOSTERONE and serum GLUCOSE compared to the control group. While, administration of FLUOXETINE increased CORTICOSTERONE levels compared to the patient group, but administration of IMIPRAMINE induced no change. Administration of FLUOXETINE or IMIPRAMINE also increased GLUCOSE levels compared to the patient group.Conclusion: The results showed that immobilization stress causes depression-like behavior, and FLUOXETINE compared to IMIPRAMINE has more improving effects in the reduction of depression-like behavior.

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APA: Copy

BAYRAMLOU, RAZIEH, MOHAMMADZADEH, MEHDI, & BABAEI BALDERLOU, FARIN. (2018). A COMPARATIVE SURVEY OF THE EFFECTS OF FLUOXETINE AND IMIPRAMINE ON DEPRESSION-LIKE BEHAVIOR AND SERUM LEVELS OF CORTICOSTERONE AND GLUCOSE IN MALE RATS UNDER IMMOBILIZATION STRESS. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 12(2 ), 1-10. SID. https://sid.ir/paper/132494/en

Vancouver: Copy

BAYRAMLOU RAZIEH, MOHAMMADZADEH MEHDI, BABAEI BALDERLOU FARIN. A COMPARATIVE SURVEY OF THE EFFECTS OF FLUOXETINE AND IMIPRAMINE ON DEPRESSION-LIKE BEHAVIOR AND SERUM LEVELS OF CORTICOSTERONE AND GLUCOSE IN MALE RATS UNDER IMMOBILIZATION STRESS. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2018;12(2 ):1-10. Available from: https://sid.ir/paper/132494/en

IEEE: Copy

RAZIEH BAYRAMLOU, MEHDI MOHAMMADZADEH, and FARIN BABAEI BALDERLOU, “A COMPARATIVE SURVEY OF THE EFFECTS OF FLUOXETINE AND IMIPRAMINE ON DEPRESSION-LIKE BEHAVIOR AND SERUM LEVELS OF CORTICOSTERONE AND GLUCOSE IN MALE RATS UNDER IMMOBILIZATION STRESS,” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 12, no. 2 , pp. 1–10, 2018, [Online]. Available: https://sid.ir/paper/132494/en

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