THE EFFECT OF BISPHENOL A ON LIVER TISSUE STRUCTURE AND LIVER ENZYMES

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RAHIMI OZRA; FAROKHI FARAH; BANAN KHOJASTEH SEYED MAHDI

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Journal: Qom University of Medical Sciences Journal Year:2016 | Volume:9 | Issue:12 Page(s): 1-7

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Title

THE EFFECT OF BISPHENOL A ON LIVER TISSUE STRUCTURE AND LIVER ENZYMES

Author(s)

RAHIMI OZRA | FAROKHI FARAH | BANAN KHOJASTEH SEYED MAHDI | Issue Writer Certificate

Keywords

LIVERQ2

INFLAMMATIONQ2

BISPHENOL AQ2

Abstract

Background and Objectives: BISPHENOL A (BPA) is one of the chemical materials, which is used as monomer of epoxy resins and polycarbonate plastics. The present study was performed with the purpose of determining the effect of A on LIVER enzymes level and LIVER tissue structure.Methods: In this experimental study 40 male rats were divided into 4 groups of 10 each: The control group received olive oil at a dose of 1mg/kg bw; group II received BPA at 10mg/kg bw; group III received BPA at 50mg/kg bw; and group IV received BPA at 100mg/kg bw). The groups were administered BPA intraperitoneally for 15 days. At the end, the rats were anesthetized and after extraction of serum, their LIVER were removed for examination of LIVER enzymes and evaluated by light microscopy after H& E staining.Results: The doses of 10 and 50mg/kg bw of BPA had no significant effect on ALT enzyme and 10mg/kg bw had no significant effect on AST enzyme (p>0.05), while BPA at dose of 100 and doses 50 and 100mg/kg bw had significant effects on ALT and AST, respectively, and increased their serum concentration. BPA only at dose of 100mg/kg bw caused INFLAMMATION and vacuolization in LIVER tissue, and its low concentrations had no significant effect on the LIVER tissue.Conclusion: The results indicated that low concentrations of BPA had no significant effect on LIVER tissue and enzymes, but its increased concentration can cause damage to LIVER tissue and increase the serum levels of LIVER enzymes.

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APA: Copy

RAHIMI, OZRA, FAROKHI, FARAH, & BANAN KHOJASTEH, SEYED MAHDI. (2016). THE EFFECT OF BISPHENOL A ON LIVER TISSUE STRUCTURE AND LIVER ENZYMES. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 9(12), 1-7. SID. https://sid.ir/paper/132505/en

Vancouver: Copy

RAHIMI OZRA, FAROKHI FARAH, BANAN KHOJASTEH SEYED MAHDI. THE EFFECT OF BISPHENOL A ON LIVER TISSUE STRUCTURE AND LIVER ENZYMES. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2016;9(12):1-7. Available from: https://sid.ir/paper/132505/en

IEEE: Copy

OZRA RAHIMI, FARAH FAROKHI, and SEYED MAHDI BANAN KHOJASTEH, “THE EFFECT OF BISPHENOL A ON LIVER TISSUE STRUCTURE AND LIVER ENZYMES,” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 9, no. 12, pp. 1–7, 2016, [Online]. Available: https://sid.ir/paper/132505/en

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