Protective Effect of Egg Yolk Immunoglobulin (IgY) Against Aflatoxin on Blood Parameters, Ileum Morphometry and Hepatocytes’ Histopathology of Broiler Chickens Fed Aflatoxin B1

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NAKHAEI ALI; AFZALI NAZAR; HOSSEINI VASHAN SEYYED JAVAD; KARIMI TORSHIZI MOHAMMAD AMIR

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Journal: IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY Year:2018 | Volume:12 | Issue:3 Page(s): 199-207

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Title

Protective Effect of Egg Yolk Immunoglobulin (IgY) Against Aflatoxin on Blood Parameters, Ileum Morphometry and Hepatocytes’ Histopathology of Broiler Chickens Fed Aflatoxin B1

Author(s)

NAKHAEI ALI | AFZALI NAZAR | HOSSEINI VASHAN SEYYED JAVAD | KARIMI TORSHIZI MOHAMMAD AMIR | Issue Writer Certificate

Keywords

Aflatoxin B1Q1

Blood parametersQ1

Specific immunoglobulinQ1

Abstract

Background and Aims: The aim of this study was to evaluate the protective effect of specific egg yolk immunoglobulin (IgY) against aflatoxin on reducing the defects of aflatoxin by adding to the drinking water of 192 day Ross 308 broiler chickens from 1 to 42 days old. Materials and Methods: The experiment was based on a completely randomized design with 6 treatments, 4 replications, and 8 observations (chicks). First egg yolks were immunized against aflatoxin by injecting aflatoxin-BSA conjugate to laying hens. Also extracted immunoglobulin with 1 and 0. 5 percent /volume concentration was added to broilers' drinking water. The experimental treatments were: 1) control (without any additives); 2) ration contaminated with 1 mg kg-1 Aflatoxin B1 (negative control treatment); 3) negative control + 0. 5% (V/V) immunized yolk against AFB1, 4) negative control + 0. 5% (V/V) unimmunized yolk against AFB1; 5) negative control + 1% (V/V) immunized yolk against AFB1 and 6) negative control + 1% (V/V) unimmunized yolk against AFB1. Results: Using aflatoxin contaminated diet significantly increased serum cholesterol, and decreased serum total protein and albumin concentration (P<0. 05). Also, histopathologic lesions observed in the liver. Adding 1 % (V/V) of immunized egg yolk to the drinking water (treatment 5) reduced serum cholesterol and increased total protein concentration compared to treatment 2 (P<0. 05). The length and width of the villi and the villi surface area of chicks receiving treatment 5 were higher than treatment 2 (P<0. 05). Liver tissue in chicken receiving treatment 3 and 5, was almost normal and few changes were observed in hepatocytes. Conclusions: The results indicate that specific IgY against AFB1 can be effective in reducing the defects of experimental aflatoxicosis as a detoxification agent.

Cites

Assessment of Lactobacillus Delbruekii and Bifidobacterium Animalis Abilities to Absorb Aflatoxin M1 from Milk

References

IgY reduces AFB1-induced cytotoxicity, cellular dysfunction, and genotoxicity in human L-02 hepatocytes and Swan 71 trophoblasts

Cite

APA: Copy

NAKHAEI, ALI, AFZALI, NAZAR, HOSSEINI VASHAN, SEYYED JAVAD, & KARIMI TORSHIZI, MOHAMMAD AMIR. (2018). Protective Effect of Egg Yolk Immunoglobulin (IgY) Against Aflatoxin on Blood Parameters, Ileum Morphometry and Hepatocytes’ Histopathology of Broiler Chickens Fed Aflatoxin B1. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, 12(3 ), 199-207. SID. https://sid.ir/paper/132724/en

Vancouver: Copy

NAKHAEI ALI, AFZALI NAZAR, HOSSEINI VASHAN SEYYED JAVAD, KARIMI TORSHIZI MOHAMMAD AMIR. Protective Effect of Egg Yolk Immunoglobulin (IgY) Against Aflatoxin on Blood Parameters, Ileum Morphometry and Hepatocytes’ Histopathology of Broiler Chickens Fed Aflatoxin B1. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY[Internet]. 2018;12(3 ):199-207. Available from: https://sid.ir/paper/132724/en

IEEE: Copy

ALI NAKHAEI, NAZAR AFZALI, SEYYED JAVAD HOSSEINI VASHAN, and MOHAMMAD AMIR KARIMI TORSHIZI, “Protective Effect of Egg Yolk Immunoglobulin (IgY) Against Aflatoxin on Blood Parameters, Ileum Morphometry and Hepatocytes’ Histopathology of Broiler Chickens Fed Aflatoxin B1,” IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, vol. 12, no. 3 , pp. 199–207, 2018, [Online]. Available: https://sid.ir/paper/132724/en

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