Comparison of Platelet-Rich Plasma (PRP), Bone Marrow-Derived Mesenchymal Stem Cells and their Combination on the Healing of Achilles tendon in Rabbits

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

BAGHERI FARNOOSH; TAVASOLY ABBAS; Dehgahan Mohammad Mehdi; SASANI FARHANG; RAJI MINA; Farzad Mohajeri Saeed

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Veterinary Surgery Year:2017 | Volume:12 | Issue:2 (27) Page(s): 44-52

Download Full-Text

Persian Verion

View:

536

Download:

104

Cites:

Information Journal Paper

Title

Comparison of Platelet-Rich Plasma (PRP), Bone Marrow-Derived Mesenchymal Stem Cells and their Combination on the Healing of Achilles tendon in Rabbits

Author(s)

Keywords

Tendon histologic scoringQ1

PRPQ1

MSCsQ2

RabbitQ1

Abstract

Objectives-The purpose of the study was to observe whether PRP, Mesenchymal Stem Cells (MSCs) and combining them could help make improvements the healing of Achilles tendons in Rabbits. Design-Experimental study. Animals-Sixteen male, healthy and mature white New Zealand Rabbits. Procedures-The animals were randomiaed into 4 groups: Control, PRP, MSCs with fibrin glue and MSCs + PRP therapy. A 3 mm diameter defect was created in the midsubstance of the medial M. gastrocnemius tendon in all Rabbits. After 4 and 8 weeks, animals were euthanized (each time point, 2 Rabbits of the each group) and samples were examined in term of histologic scoring with H & E and Masson's Trichrome. Results-Histologic investigations confirmed that all 3 methods of treatment in Achilles tendon defect had suitable reparative effects. Final histologic scoring for control group at 4th week after operation was 4. 5 in contrast to treatment groups (PRP =6, MSCs = 5. 5 and MSCs + PRP= 8). Final histologic scoring in all 4 groups improved at 8th week after operation (control=6. 5, PRP =9. 5, MSCs = 8. 5 and MSCs + PRP= 14. 5). Conclusion and Clinical Relevance-This study indicated that using PRP or MSCs treatment alone and combination of them in injured tendon improved healing process and decreased time of repair. Reparative effect of PRP in tendon defect was better than use of allogenic MSCs treatment. However, the combination of them caused the best results.

Cites

No record.

References

No record.

Cite

APA: Copy

BAGHERI, FARNOOSH, TAVASOLY, ABBAS, Dehgahan, Mohammad Mehdi, SASANI, FARHANG, RAJI, MINA, & Farzad Mohajeri, Saeed. (2017). Comparison of Platelet-Rich Plasma (PRP), Bone Marrow-Derived Mesenchymal Stem Cells and their Combination on the Healing of Achilles tendon in Rabbits. IRANIAN JOURNAL OF VETERINARY SURGERY (IJVS), 12(2 (27) ), 44-52. SID. https://sid.ir/paper/135754/en

Vancouver: Copy

BAGHERI FARNOOSH, TAVASOLY ABBAS, Dehgahan Mohammad Mehdi, SASANI FARHANG, RAJI MINA, Farzad Mohajeri Saeed. Comparison of Platelet-Rich Plasma (PRP), Bone Marrow-Derived Mesenchymal Stem Cells and their Combination on the Healing of Achilles tendon in Rabbits. IRANIAN JOURNAL OF VETERINARY SURGERY (IJVS)[Internet]. 2017;12(2 (27) ):44-52. Available from: https://sid.ir/paper/135754/en

IEEE: Copy

FARNOOSH BAGHERI, ABBAS TAVASOLY, Mohammad Mehdi Dehgahan, FARHANG SASANI, MINA RAJI, and Saeed Farzad Mohajeri, “Comparison of Platelet-Rich Plasma (PRP), Bone Marrow-Derived Mesenchymal Stem Cells and their Combination on the Healing of Achilles tendon in Rabbits,” IRANIAN JOURNAL OF VETERINARY SURGERY (IJVS), vol. 12, no. 2 (27) , pp. 44–52, 2017, [Online]. Available: https://sid.ir/paper/135754/en

Related Journal Papers