A simple and efficient route for the synthesis of 3-amino aryl -5-aryl -1,2,4-triazoles and investigation of the antibacterial activity

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Lazar Manouchehri Arezoo; Pourshamsian Khalil

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Journal Paper

Paper Information

Journal: International Journal of Molecular and Clinical Microbiology Year:2023 | Volume:13 | Issue:2 Page(s): 1880-1888

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Information Journal Paper

Title

A simple and efficient route for the synthesis of 3-amino aryl -5-aryl -1,2,4-triazoles and investigation of the antibacterial activity

Author(s)

Lazar Manouchehri Arezoo | Pourshamsian Khalil | Issue Writer Certificate

Keywords

Hydrazine

Thioureas derivatives

Triazoles derivatives

Antibacterial

Well Diffusion Method

Abstract

Heterocycles containing nitrogen element show many medicinal properties. Among them, triazoles show significant anticancer and antifungal properties. Because of the useful properties of these compounds, chemists have always been looking for an easier and more effective way to synthesize these compounds. In this study, ten novel 3-aminoaryl -5-aryl-1,2,4-triazoles derivatives were prepared via the reaction of N-acyl-N′-aryl thioureas and Hydrazine hydrate in the reflux conditions and characterized by analytical and spectral analyses. In this study, the Antibacterial properties of the compounds synthesized by the Well Diffusion Method were investigated. All compounds showed good Antibacterial properties against Staphylococcus aureus and Escherichia coli bacteria. Compounds 3g, 3f and 3j had the most Antibacterial effect.

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