Investigating the antibacterial effects of polyvinyl alcohol/polyvinyl pyrrolidone composite nanofiber mat containing clindamycin

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Yousefi Mogadam S.; Ziyadi H.; Hekmati M.; Seyedi F.

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ISSN: 2588-4824

Journal Paper

Paper Information

Journal: Journal of Applied Research in Chemistry Year:2023 | Volume:17 | Issue:4 Page(s): 24-39

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Title

Investigating the antibacterial effects of polyvinyl alcohol/polyvinyl pyrrolidone composite nanofiber mat containing clindamycin

Author(s)

Yousefi Mogadam S. | Ziyadi H. | Hekmati M. | Seyedi F. | Issue Writer Certificate

Keywords

NanofiberQ4

ClindamycinQ4

Staphylococcus aureusQ4

Pseudomonas aeruginosaQ4

Acinetobacter.Q4

Abstract

Due to the expansion and importance of nano fibers in the field of pharmaceutical sciences and the ability to use them as skin patches, in this study, Nanofibers carrying Clindamycin was obtained from adding pure Clindamycin to poly(vinyl alcohol) and poly(vinyl pyrrolidone) polymers fallowed by electrospinning of polymeric solution. The obtained Nanofibers were analyzed by Fourier transform infrared spectroscopy (FTIR), atomic force microscope (AFM), scanning electron microscope (SEM), Energy dispersive X-ray spectroscopy (EDS), Element Mapping (EMPA), and contact angle analysis. The nature of the bond between Clindamycin drug and poly(vinyl alcohol)/poly(vinyl pyrrolidone) substrate was investigated using the quantum theory of atoms in molecules (QTAIM). Antibacterial effects of non-electrospun polymer solution and obtained Nanofibers mats were investigated on standard strains of Pseudomonas aeruginosa, Acinetobacter.and Staphylococcus aureus bacteria. According to the obtained results, Pseudomonas aeruginosa bacteria was resistant to non-electrospun polymer solution and Clindamycin nanofibrous mats. Acinetobacter.bacteria was resistant to polymer solution, but Clindamycin Nanofiber had moderate effect on it. Clindamycin Nanofibers mats and non-electrospun polymer solution were very effective against Staphylococcus aureus bacteria. Therefore, Clindamycin nanofibrous mats can be used as transdermal patches to treat infections caused by Staphylococcus aureus and Acinetobacter.bacteria. In addition, the polymer solution can be useful as a medicinal solution in the transdermal treatment of Staphylococcus aureus bacterial infections.

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