The Effect of High-Intensity Interval Training on the Amount of BECLIN1/2 Family Autophagy Proteins in the Left Ventricle of the Heart in Rats with Type 1 Diabetes

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Alizadeh Palavani Hamed; Yaghmaei Mehdi; Mirzaee Moghamir Sanam; Salboukhi Reza

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Journal Paper

Paper Information

Journal: Iranian Journal of Diabetes and Metabolism Year:2023 | Volume:23 | Issue:4 Page(s): 236-244

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Title

The Effect of High-Intensity Interval Training on the Amount of BECLIN1/2 Family Autophagy Proteins in the Left Ventricle of the Heart in Rats with Type 1 Diabetes

Author(s)

Alizadeh Palavani Hamed | Yaghmaei Mehdi | Mirzaee Moghamir Sanam | Salboukhi Reza | Issue Writer Certificate

Keywords

BECLIN 1/2 ProteinsQ4

High-Intensity Interval TrainingQ4

Type 1 DiabetesQ4

Left Ventricle HeartQ4

Abstract

2Background: Several proteins regulate the autophagy pathway, and one of the most important regulators is the BECLIN family proteins. Therefore, this research aims to investigate the effect of High-Intensity Interval Training on the amount of BECLIN1/2 family autophagy proteins in the left ventricle of the heart of rats with Type 1 Diabetes. Methods: In this experimental study, 18 three-month-old male Sprague Dawley rats with an average weight of 300±20 grams were selected. 12 rats were diagnosed with Type 1 Diabetes through intraperitoneal injection of streptozotocin solution. These rats were randomly divided into two groups, diabetic exercise, and diabetic control,A healthy control group was also considered,The HIIT was performed for 6 weeks and 4 sessions each week including 5 bursts of 4 minutes with an intensity equal to 85-95% of the maximum speed and 3-minute active rest periods with an intensity equal to 50-60% of the maximum speed. Data analysis was done through one-way ANOVA and Tukey's post hoc tests in SPSS version 26 software. A significance level of 0. 05 was considered. Results: The intracellular content of BECLIN1 and BECLIN2 protein showed a significant decrease between the research groups in the left ventricle of the heart after six weeks of HIIT (p=0. 0001). Conclusion: It seems that BECLIN family proteins are decreased by HIIT and this can decrease the autophagy mechanism in cardiac cells

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