Effect of eight weeks of high-intensity interval training and moderate-intensity continuous training with quercetin supplementation on the gene expression of FOXO1 and ATG5 in the liver of diabetic obese rats

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Seifi Farnaz; Khajehlandi Mojdeh

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Journal Paper

Paper Information

Journal: Jorjani Biomedicine Journal Year:2023 | Volume:11 | Issue:4 Page(s): 19-23

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Title

Effect of eight weeks of high-intensity interval training and moderate-intensity continuous training with quercetin supplementation on the gene expression of FOXO1 and ATG5 in the liver of diabetic obese rats

Author(s)

Seifi Farnaz | Khajehlandi Mojdeh | Issue Writer Certificate

Keywords

High-intensity interval trainingQ4

Endurance TrainingQ4

AutophagyQ4

FOXO1 ProteinQ4

HumanQ4

ATG5 ProteinQ4

HumanQ4

LiverQ4

Diabetes MellitusQ4

Type 2Q4

Abstract

Background: The use of complementary medicine in healthcare is increasing rapidly. Therefore, the aim of the current study was to investigate the effect of eight weeks of High-intensity interval training and moderate-intensity continuous training with quercetin supplementation on the gene expression of FOXO1 and ATG5 in the Liver of diabetic obese rats. Methods: In this experimental study, 42 male Wistar rats were considered research samples at eight weeks. Rats were induced with diabetes after eight weeks of a high-fat diet and familiarization with a laboratory environment and treadmill. Rats were divided into seven groups, and six rats were placed in each group (n=6): healthy control group, diabetes control group, diabetic quercetin group, High-intensity interval training with diabetes group, moderate-intensity continuous training with diabetes group, diabetic High-intensity interval training with quercetin group, and diabetic moderate-intensity continuous training with quercetin group. For one training group, eight weeks of High-intensity interval training, and for the other group, eight weeks of moderate-intensity continuous training on the treadmill were performed. Seventy-two hours after the last training session, Liver tissues were isolated to check the gene expression of FOXO1 and ATG5. One-way analysis of variance test was used to check the difference between groups by SPSS version 26 software. Results: Findings showed that by inducing Type 2 diabetes, gene expression of FOXO1 increased (3.14 unit) (P<0.001) and ATG5 gene expression decreased (0.71 unit) (P<0.001). After eight weeks of training investigation, gene expression of FOXO1 and ATG5 decreased (P<0.001) and increased (P<0.001), respectively, in all training groups compared to the diabetic control group. There was no significant difference between the four training groups (P>0/05). Conclusion: Both exercises with and without quercetin had a modulating effect on the gene expression of indicators related to the process of Autophagy and blood glucose levels in the Liver of diabetic obese rats.

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