Effects of saffron hydro-alcoholic extract on the hippocampal oligodendrocyte transcription factor 2 and glial fibrillary acidic 
protein distribution in female demyelinated rats

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Javid Zahra; Taherianfard Mahnaz; Sajedianfard Javad; Moradi Hamid Reza

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Journal Paper

Paper Information

Journal: Iranian Journal of Physiology and Pharmacology Year:2023 | Volume:7 | Issue:1 Page(s): 19-31

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Title

Effects of saffron hydro-alcoholic extract on the hippocampal oligodendrocyte transcription factor 2 and glial fibrillary acidic protein distribution in female demyelinated rats

Author(s)

Javid Zahra | Taherianfard Mahnaz | Sajedianfard Javad | Moradi Hamid Reza | Issue Writer Certificate

Keywords

‎Glial fibrillary acidic protein

Demyelination

Blood Brain Barrier

Oligodendrocyte transcription factor

Abstract

Background and aim: Demyelinating diseases are autoimmune disorders of the nervous system. The present study aims to effect of the hydro-alcoholic extract of saffron on blood brain-barrier destruction, Glial fibrillary acidic protein, and Oligodendrocyte transcription factor 2 distribution in astrocyte and oligodendroglia cells and the number of mentioned cells. Methods: Forty female Sprague Dawley adult rats in four groups, Sham, treatment control, saffron treatment, and infliximab treatment were used. Demyelination was induced by 3 µl of 0.01% ethidium bromide injection in the dentate gyrus. Immunohistochemistry was used, for the distribution of Glial fibrillary acidic protein and Oligodendrocyte transcription factor 2 determination. The Image Analyzer software have evaluated the distribution of Glial fibrillary acidic protein and Oligodendrocyte transcription factor 2. Demyelination was determined by Luxol fast blue staining and image-j software. The ELISA method and Evans blue extravasation measurement have investigated the extent of blood brain-barrier disruption. Results: Blood brain-barrier disruption was meaningfully (p < 0.05) more in the treatment control compared to the other groups. The distribution of Glial fibrillary acidic protein and Oligodendrocyte transcription factor 2 and the number of both cells were considerably (p < 0.001) lower in the treatment control relative to the other groups. Glial fibrillary acidic protein and Oligodendrocyte transcription factor 2 remarkably (p < 0.05) were lesser in the treatment control compared to the other groups. Conclusion: The hydro-alcoholic extract of saffron ameliorates blood brain-barrier destruction, improved Glial fibrillary acidic protein, and Oligodendrocyte transcription factor 2 distribution and number of astrocyte and oligodendroglia cells.

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