High clarithromycin resistance of Helicobacter pylori strains isolated from naive patients

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Rezaei Shiva; Talebi Bezmin Abadi Amin; Mohabatti Mobarez Ashraf

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Journal Paper

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Journal: Pathobiology Research Year:2023 | Volume:26 | Issue:2 Page(s): 69-74

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Information Journal Paper

Title

High clarithromycin resistance of Helicobacter pylori strains isolated from naive patients

Author(s)

Rezaei Shiva | Talebi Bezmin Abadi Amin | Mohabatti Mobarez Ashraf | Issue Writer Certificate

Keywords

Helicobacter pylori

resistance

clarithromycin

susceptibility test

Abstract

Introduction This study investigates the susceptibility and resistance of H. pylori isolates recovered from gastroduodenal patients naive to clarithromycin. Methods To that end, H. pylori strains were isolated from antral biopsies of pretreatment patients, and antral biopsy specimens were subsequently cultured. Presumptive H. pylori colonies were also confirmed on enriched Brucella agar by biochemical tests, including catalase, oxidase, rapid urease, and the standard polymerase chain reaction (PCR) method. The antimicrobial susceptibility testing was performed by standard disk diffusion methods according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. Then, the Epsilometer test (E-test) was used to determine the minimal inhibition concentration (MIC). Results Of 180 samples, 80 (44%) were positive for urease and were included for further analysis. 65 were also positive in culture base method. The sensitivity test indicated a 23% resistance rate to clarithromycin among the six clarithromycin-resistant strains: four have a common form of the A2143G mutation, and two have A2142G mutation. Conclusion The PCR indicated that the level of resistance to clarithromycin was very similar to the resistance level in Iran.

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