INTERACTION BETWEEN HER-2 AND HORMONE RECEPTORS IN BREAST CANCER

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOGHADASZADEH MAJID; NIKANFAR ALIREZA; HEMATI MOHAMADREZA; MOGHADASZADEH MASOUD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Breast Diseases Year:2010 | Volume:2 | Issue:3-4 Page(s): 7-11

Download Full-Text

Persian Verion

View:

2,497

Download:

Cites:

Information Journal Paper

Title

INTERACTION BETWEEN HER-2 AND HORMONE RECEPTORS IN BREAST CANCER

Author(s)

MOGHADASZADEH MAJID | NIKANFAR ALIREZA | HEMATI MOHAMADREZA | MOGHADASZADEH MASOUD | Issue Writer Certificate

Keywords

BREAST CANCERQ2

HER-2Q4

HORMONE RECEPTORSQ4

Abstract

Introduction: The most common malignancy, with more than one million new case per year in the world, is BREAST CANCER. The progression of BREAST CANCER in human is mostly regulated with steroidal hormones such as estrogen and peptide growth factors which are interacted with epidermal growth factor 1 and 2. HORMONE RECEPTORS level is low in normal breast tissue but high in two third of BREAST CANCER.Material and Methods: In this study, 237 patients who had referred to the oncology clinic of Tabriz University of Medical Sciences with diagnosis of BREAST CANCER (from 1382 through 1388) were involved. The variant data was extracted from the medical record. Data was analyzed by SPSS software and proper statistical examination.Results: From the total of 237 patients, 50.6% were ER+, 48.9% were PR+ and 37.1% were HER-2+. The greatest percentage of HER-2+(51.6%) was in the ages over 60 and the least in the group age 31-40 yrs. The greatest percentage of HR+(71%) was also in patients over 60 and the least (50%) in patients less than 30. 35.5% of patients in pre-menstrual period were HER-2+, at the time that HR+ percentage was 64% in LN+ patients, percentage of HER-2+ and HR+ was 35.4% and 65.4% while in LN- patients it was 39% and 61.9% respectively. The greatest positive rate of HER-2 was at stage I and HR+ was related to stage IV.Discussion: Acquired data showed to be in inverse ratio between the rate of expression of epidermal growth factor II and HORMONE RECEPTORS in BREAST CANCER. 40-55% of samples with expression of epidermal growth factors lacked HORMONE RECEPTORS. Existence of both HORMONE RECEPTORS and expression of HER-2 in BREAST CANCER are considered as important prognostic factors.

Cites

No record.

References

No record.

Cite

APA: Copy

MOGHADASZADEH, MAJID, NIKANFAR, ALIREZA, HEMATI, MOHAMADREZA, & MOGHADASZADEH, MASOUD. (2010). INTERACTION BETWEEN HER-2 AND HORMONE RECEPTORS IN BREAST CANCER. IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE, 2(3-4), 7-11. SID. https://sid.ir/paper/144696/en

Vancouver: Copy

MOGHADASZADEH MAJID, NIKANFAR ALIREZA, HEMATI MOHAMADREZA, MOGHADASZADEH MASOUD. INTERACTION BETWEEN HER-2 AND HORMONE RECEPTORS IN BREAST CANCER. IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE[Internet]. 2010;2(3-4):7-11. Available from: https://sid.ir/paper/144696/en

IEEE: Copy

MAJID MOGHADASZADEH, ALIREZA NIKANFAR, MOHAMADREZA HEMATI, and MASOUD MOGHADASZADEH, “INTERACTION BETWEEN HER-2 AND HORMONE RECEPTORS IN BREAST CANCER,” IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE, vol. 2, no. 3-4, pp. 7–11, 2010, [Online]. Available: https://sid.ir/paper/144696/en

Related Journal Papers