EXPRESSION OF CK19 GENE IN PATIENTS WITH LUNG CANCER AND ITS COMPARISON WITH CARCINOEMBRYONIC ANTIGEN IN PERIPHERAL BLOOD

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOHAMADNIA ABDOLREZA; KARIMI SHIRIN; YADEGARAZARI REZA; NAJI SEYED ALIREZA; KHOSRAVI ADNAN; BAHRAMI NAGHMEH; SAIDIJAM MASSOUD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Payavard Salamat Year:2016 | Volume:9 | Issue:5 Page(s): 459-468

Download Full-Text

Persian Verion

View:

3,279

Download:

Cites:

Information Journal Paper

Title

EXPRESSION OF CK19 GENE IN PATIENTS WITH LUNG CANCER AND ITS COMPARISON WITH CARCINOEMBRYONIC ANTIGEN IN PERIPHERAL BLOOD

Author(s)

Keywords

LUNG CANCERQ2

BIOMARKERQ2

CK19 MRNAQ2

CARCINOEMBRYONIC ANTIGENQ2

PERIPHERAL BLOODQ2

Abstract

Background and Aim: LUNG CANCER is the most common cancer among men around the world. The aim of this study was to determine the expression levels of CK19 MRNA marker in the affected patients’ PERIPHERAL BLOOD.Materials and Methods: Thirty patients with LUNG CANCER (NSCLC type) were compared with 30 healthy controls. After taking PERIPHERAL BLOOD samples and extracting total RNA, cDNA was synthesized and examined by Real-time RT-PCR technique. Then, the CEA antigen was measured by ELISA.Results: The CK19mRNA was positive in 7 out of 30 LUNG CANCER patients.Hence, its sensitivity was determined to be 23.3 %. The serum level of CEA antigen was positive in 11 out of 30 LUNG CANCER patients. The mean serum level of CEA antigen markers was higher in patients than in controls; the difference was statistically significant (P<0.001). The sensitivity of this test was determined to be 36.6 %.Conclusion: This study showed that the sensitivity of CK19 MRNA in PERIPHERAL BLOOD was low, but it had a high specificity for the diagnosis of primary LUNG CANCER. Also, it was found that CEA antigen could be the specific marker for the early detection of LUNG CANCER in patients’ PERIPHERAL BLOOD.

Cites

DETECTION OF VASCULAR ENDOTHELIAL GROWTH FACTOR MESSENGER RNA (VEGF MRNA), CYTOKERATIN-19 MRNA (CK19 MRNA), AND VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) PROTEIN BIOMARKER IN THE PERIPHERAL BLOOD OF PATIENTS WITH BREAST CANCER

References

No record.

Cite

APA: Copy

MOHAMADNIA, ABDOLREZA, KARIMI, SHIRIN, YADEGARAZARI, REZA, NAJI, SEYED ALIREZA, KHOSRAVI, ADNAN, BAHRAMI, NAGHMEH, & SAIDIJAM, MASSOUD. (2016). EXPRESSION OF CK19 GENE IN PATIENTS WITH LUNG CANCER AND ITS COMPARISON WITH CARCINOEMBRYONIC ANTIGEN IN PERIPHERAL BLOOD. PAYAVARD-SALAMAT, 9(5), 459-468. SID. https://sid.ir/paper/149865/en

Vancouver: Copy

MOHAMADNIA ABDOLREZA, KARIMI SHIRIN, YADEGARAZARI REZA, NAJI SEYED ALIREZA, KHOSRAVI ADNAN, BAHRAMI NAGHMEH, SAIDIJAM MASSOUD. EXPRESSION OF CK19 GENE IN PATIENTS WITH LUNG CANCER AND ITS COMPARISON WITH CARCINOEMBRYONIC ANTIGEN IN PERIPHERAL BLOOD. PAYAVARD-SALAMAT[Internet]. 2016;9(5):459-468. Available from: https://sid.ir/paper/149865/en

IEEE: Copy

ABDOLREZA MOHAMADNIA, SHIRIN KARIMI, REZA YADEGARAZARI, SEYED ALIREZA NAJI, ADNAN KHOSRAVI, NAGHMEH BAHRAMI, and MASSOUD SAIDIJAM, “EXPRESSION OF CK19 GENE IN PATIENTS WITH LUNG CANCER AND ITS COMPARISON WITH CARCINOEMBRYONIC ANTIGEN IN PERIPHERAL BLOOD,” PAYAVARD-SALAMAT, vol. 9, no. 5, pp. 459–468, 2016, [Online]. Available: https://sid.ir/paper/149865/en

Related Journal Papers